TITLE

Lumiracoxib reduced ulcer complications compared with ibuprofen and naproxen in osteoarthritis and did not increase cardiovascular outcomes

PUB. DATE
March 2005
SOURCE
ACP Journal Club;Mar/Apr2005, Vol. 142 Issue 2, p46
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article cites a study which presents a comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial. The study was published in the 2004 issue of the journal "Lancet." In all patients and in those not taking low-dose aspirin, fewer patients who received lumiracoxib had definite or probable upper gastrointestinal ulcer complications than did those taking ibuprofen or naproxen. No difference was seen among patients taking lowdose aspirin. The rate of the composite cardiovascular endpoint did not differ between the lumiracoxib and nonsteroidal antiinflammatory drugs groups. Groups also did not differ when analyzed by aspirin use.
ACCESSION #
16486593

 

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