COMMENTARY: Gly/Gly and Arg/Arg genotype responses to albuterol differed in mild asthma

Abramson, Michael J.
March 2005
ACP Journal Club;Mar/Apr2005, Vol. 142 Issue 2, p43
Academic Journal
The article comments on a study which discusses the use of regularly scheduled albuterol treatment in asthma. The study was underpowered to detect a statistically significant effect on exacerbations in patients with mild asthma. Although many respiratory studies focus on lung function, it is unfortunate that health-related quality of life or other patient-important outcomes were not assessed. The study used three methods of genotyping, which are not all widely available. Almost half the patients screened were ineligible, presumably because they were heterozygous for this polymorphism. The prevalence of the Arg/Arg genotype is lower in some other populations.


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