Gly/Gly and Arg/Arg genotype responses to albuterol differed in mild asthma

March 2005
ACP Journal Club;Mar/Apr2005, Vol. 142 Issue 2, p43
Academic Journal
The article cites a study which discusses the use of regularly scheduled albuterol treatment in asthma. The study was published in the 2004 issue of the journal "Lancet." In mild asthma, patients with the Gly/Gly genotype had better asthma control with albuterol than when it was withdrawn, and patients with the Arg/Arg genotype had worse asthma control with albuterol than when it was withdrawn. Each patient with the Arg/Arg genotype was matched with a patient with the Gly/Gly genotype by FEV. In patients with Gly/Gly genotype, morning PEFR improved with albuterol and no significant change was seen with placebo.


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