Peginterferon α-2a alone or combined with lamivudine increased response rates more than lamivudine alone

March 2005
ACP Journal Club;Mar/Apr2005, Vol. 142 Issue 2, p34
Academic Journal
The article cites a study related to the efficacy and safety of peginterferon α-2a monotherapy, peginterferon α-2a plus lamivudine and lamivudine monotherapy in patients with hepatitis B e antigen (HBeAg)-negative chronic hepatitis B. In patients with hepatitis B e antigen-negative chronic hepatitis B, peginterferon α-2a monotherapy and peginterferon α-2a plus lamivudine increased rates of normalization of alanine aminotransferase levels and suppression of hepatitis B virus DNA levels to < 20 000 copies/mL. The study was published in the 2004 issue of the "New England Journal of Medicine."


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