COMMENTARY: Caspofungin was noninferior to amphotericin B for invasive fungal infections in persistent fever and neutropenia and was better tolerated

Glatt, Aaron E.
March 2005
ACP Journal Club;Mar/Apr2005, Vol. 142 Issue 2, p33
Academic Journal
The article reports that febrile neutropenia remains one of the most serious complications of cancer chemotherapy. Most patients require empiric treatment by algorithm to cover the most likely pathogens. Liposomal amphotericin B (AB) and fluconazole are no longer preferred as initial choices because of efficacy, resistance, and toxicity concerns. Many infectious disease specialists prefer liposomal AB, voriconazole, or CF as empiric regimens. The article states that caspofungin is noninferior to amphotericin B for invasive fungal infections in persistent fever and neutropenia.


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