Review: Glucocorticoids reduced mortality in sepsis in recent (post-1997) but not previous (pre-1989) trials, or all trials combined

March 2005
ACP Journal Club;Mar/Apr2005, Vol. 142 Issue 2, p31
Academic Journal
The article cites a survey of studies related to the effectivity of glucocorticoids in patients with sepsis. Studies were selected if they were randomized controlled trials (RCTs) that enrolled adult patients with sepsis or septic shock, had a primary endpoint and compared glucocorticoids with a control intervention with or without placebo. Of 4 recent RCTs that reported mortality and reversal of shock, more patients who received glucocorticoids survived and had reversal of shock. The study was published in the March 2004 issue of the journal "Ann International Medicine."


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