TITLE

COMMENTARY: Review: Low-dose but not high-dose corticosteroids reduced all-cause mortality in severe sepsis and septic shock

AUTHOR(S)
Meade, Maureen
PUB. DATE
March 2005
SOURCE
ACP Journal Club;Mar/Apr2005, Vol. 142 Issue 2, p30
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article focuses on the effect of low-dose and high-dose corticosteroids (CS) in the reduction of severe sepsis and septic shock. Clinicians and researchers have hypothesized 2 distinct mechanisms of CS therapy, which might improve outcomes for patients with severe sepsis. The first premise is that high-dose CSs suppress the deleterious and uncontrolled systemic inflammatory response of severe sepsis. The second theory is that relatively low doses of CSs address the physiologic needs of patients with sepsis-associated adrenal insufficiency.
ACCESSION #
16486563

 

Related Articles

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics