TITLE

Aortic Connective Tissue in Atherosclerotic Aorta--A Biochemical Study

AUTHOR(S)
Andreotti, Lupo; Bussotti, Alessandro; Cammelli, Daniele; Di Giovine, Francesco; Sterrantino, Gaetana; Varcasia, Giuseppe; Arcangeli, Paolo
PUB. DATE
October 1986
SOURCE
Angiology;Oct1986, Vol. 37 Issue 10, p735
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Biochemical analysis of the extracellular matrix of human aortas was performed on samples of ascending and descending aortas affected by atherosciero sis In comparison with a control group of nonatheroscierotic aortas. Ulcerated or heavily calcified atheromas were excised and excluded from the analysis in order to differentiate biochemical alterations leading to the formation of atheroma.s from those due to complications of already formed atheromas. Our results show that the development of atheromas brings about an extensive destruction of elastic fibers and muscular cells, and their place is occupied by other components of the extracellular matrix, most notably, collagen, non-uronic sugars, water, and lipids, which were found significantly increased.
ACCESSION #
16479214

 

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