Aortic Connective Tissue in Atherosclerotic Aorta--A Biochemical Study

Andreotti, Lupo; Bussotti, Alessandro; Cammelli, Daniele; Di Giovine, Francesco; Sterrantino, Gaetana; Varcasia, Giuseppe; Arcangeli, Paolo
October 1986
Angiology;Oct1986, Vol. 37 Issue 10, p735
Academic Journal
Biochemical analysis of the extracellular matrix of human aortas was performed on samples of ascending and descending aortas affected by atherosciero sis In comparison with a control group of nonatheroscierotic aortas. Ulcerated or heavily calcified atheromas were excised and excluded from the analysis in order to differentiate biochemical alterations leading to the formation of atheroma.s from those due to complications of already formed atheromas. Our results show that the development of atheromas brings about an extensive destruction of elastic fibers and muscular cells, and their place is occupied by other components of the extracellular matrix, most notably, collagen, non-uronic sugars, water, and lipids, which were found significantly increased.


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