Salvage of Ischemic Myocardium by CLS 2210 in the Dog: A Preliminary Double-Blind Study

Szlavy, L.; Repa, I.; Szabo, Z.; de Courten, A.; Hachen, H. J.
January 1987
Angiology;Jan1987 Part 2, Vol. 38 Issue 1, p85
Academic Journal
To assess whether a cardiac lymphagogue, CLS 2210, would reduce myocardial infarct size after coronary artery ligation, studies were performed in 14 dogs. The left anterior descending coronary artery was ligated in each dog, and the dogs were randomized to either placebo or CLS 2210 treatment, which was carried on for seven days. After seven days the animals were sacrificed and the volume of infarcted myocardium was determined macroscopically on a doubles blind basis, supported by histologic examination. CLS 2210 treatment resulted in a highly significant reduction in the volume of infarcted myocardium (p < 0.001). SInce CLS 2210 is chemically and pharmacologically unrelated to hyaluronidase hut shares an action with hyaluronidase as a cardiac lymphagogue, the results offer further support for a role of myocardial lymphatlcs in the evolution of myocardial necrosis following coronary artery occlusion and provide an explanation for the mechanism by which these agents reduce myocardial infarction size.


Related Articles

  • Reversible Atrial Lead Dysfunction of DDD Pacemaker After Recent Inferior Myocardial Infarction. Chiliang Chen; Ching-Chang Fang; Shih-Pu Wang // Angiology;Jul/Aug2004, Vol. 55 Issue 4, p451 

    A patient with DDD pacemaker had pacing dysfunction following an inferior myocardial infarction. The threshold of that implanted right atrial pacing lead was abnormally high but the generator was normal. A temporary lead was inserted into the high right atrium near the appendage and near the low...

  • Ischaemic preconditioning and myocardial adaptation to serial intracoronary balloon inflation: cut from the same cloth? Faircloth, M. E.; Redwood, S. R.; Marber, M. S. // Heart;Apr2004, Vol. 90 Issue 4, p358 

    This article studies ischaemic preconditioning and myocardial adaptation to serial intracoronary balloon inflation. Elective percutaneous coronary intervention fulfils many of the criteria needed of a clinical model of ischaemic preconditioning. The timing of myocardial ischaemia can be...

  • Effect of glialin on cardiac ventricular arrhythmias and myocardial conduction system in dogs. R. Khisamutdinova; F. Zarudii; S. Gabdrakhmanova; N. Makara; N. Baschenko; V. Nazarov // Bulletin of Experimental Biology & Medicine;Mar2007, Vol. 143 Issue 3, p353 

    Abstract  Intravenous glialin in a dose of 7 mg/kg suppressed the number of ectopic contractions caused by double ligature of the left coronary artery by the method of Harris and almost 2-fold prolonged animal life-span in comparison with the control. The maximum antiarrhythmic effect of...

  • HIBERNATING MYOCARDIUM EXPRESSES A GENE PROGRAMME OF CELL SURVIVAL. Depre, C.; John, A. S.; Kim, S.-J.; Markiewicz, J.; O. F. Rimoldi; Pepper, J. R.; Dreyfus, G. D.; Penneti, D. J.; Vatner, D. E.; Camici, P.G.; Vatner, S.F. // Heart;May2004 Supplement 2, Vol. 90, pA48 

    The article focuses on a study related to hibernating myocardium (HM) that expresses a gene programme of cell survival. In 7 patients with HM awaiting bypass surgery in whom cardiovascular MR had confirmed contractile dysfunction with maintained viability, biopsies were obtained from HM and...

  • Hyperglycaemia blocks sevoflurane-induced postconditioning in the rat heart in vivo: cardioprotection can be restored by blocking the mitochondrial permeability transition pore. R. Huhn; A. Heinen; N. C. Weber; M. W. Hollmann; W. Schlack; B. Preckel // BJA: The British Journal of Anaesthesia;Apr2008, Vol. 100 Issue 4, p465 

    Background Recent studies showed that hyperglycaemia (HG) blocks anaesthetic-induced preconditioning. The influence of HG on anaesthetic-induced postconditioning (post) has not yet been determined. We investigated whether sevoflurane (Sevo)-induced postconditioning is blocked by HG and whether...

  • Impact of mitral insufficiency on reoperative coronary artery surgery in ischemic cardiomyopathy patients. Wang, Nan; Campwala, Saida; Habibipour, Saied; Hodgins, Darren; Pai, Ramdas; Razzouk, Anees // European Journal of Cardio-Thoracic Surgery;Dec2004, Vol. 26 Issue 6, p1118 

    Abstract: Objective: To determine the impact of mitral insufficiency on survival after reoperative coronary artery bypass grafting (CABG) in ischemic cardiomyopathy patients. Methods: We retrospectively studied 891 (Initial 708, Redo 183) consecutive CABG patients (1993–2002) with...

  • Magnetic resonance cardiac perfusion imaging—a clinical perspective. Hunold, Peter; Schlosser, Thomas; Barkhausen, Jörg // European Radiology;Aug2006, Vol. 16 Issue 8, p1779 

    Coronary artery disease (CAD) with its clinical appearance of stable or unstable angina and acute myocardial infarction is the leading cause of death in developed countries. In view of increasing costs and the rising number of CAD patients, there has been a major interest in reliable...

  • Myocardial Viability Does Not Predict Survival Benefit After CABG.  // MD Conference Express;May2011, p21 

    The article discusses a substudy of the Surgical Treatment for Ischemic Heart Failure Trial. The study reveals that myocardeial viability did not predict a survival benefit from surgical revascularization among patients having ischemic heart disease and left ventricular (LV) dysfunction. The...

  • Two-Vessel Coronary Artery Dissection in the Peripartum Period. Madu, Ernest C.; Kosinski, Daniel J.; Wilson, William R.; Burket, Mark W.; Fraker Jr., Theodore D.; Ansel, Gary M. // Angiology;Sep1994, Vol. 45 Issue 9, p809 

    The authors report a case of early peripartum myocardial infarction resulting from spontaneous dissection of the left anterior descending coronary artery and right coronary artery in a twenty-four-year-old woman. This is the first report of double-vessel coronary dissection involving both the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics