TITLE

Theory and Methods of Local Tissue-pO2 Monitoring in Experimental Angiology

AUTHOR(S)
Spiegel, H. U.; Hauss, J.; Schönleben, K.; Bünte, H.
PUB. DATE
January 1987
SOURCE
Angiology;Jan1987 Part 1, Vol. 38 Issue 1, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The platinum-multiwire-surface electrode after Kessler and Lübbers gives the opportunity of direct measuring of the local tissue-pO2-pressure; this 8-wire electrode with a Pt-wire-diameter of 15 µm operates on the polarographic principle. Each Pt-wire has a hemispheric collecting area of about 30 µm. Pressure ischemia by compression of capillaries is prevented by proportioning the weight (2.1 g) of the electrode. Data output is done by 1) continuous pO2 measuring; 2) pO22 histograms. During the continuous pO22 measurement the electrode stays on the tissue measuring point thus enabling the direct record of quickly proceeding reactions. The pO22-histogram exhibits the statistical distribution of the local partial oxygen pressures in a studied organ, a quasi sample inquiry is performed in the tissue, based on minimum 100 single values that are obtained by repeated manual repositioning of the electrode. By this, values are obtained on the level and distribution of local pO21 in the tissue so that condition and function of the microcirculation can be objectively assessed. Immediate alterations in the local tissue pO2 suggest regulatory adjustment after hemodynamic changes. Technical problems connected with pO2 measurement in clinical use (sterilization, data acquisition and presentation) are described. The presented technique gives the chance to exactly assess the effects of vasoactive drugs on the microcirculation and to quantify the results of operations, for example after bypass-surgery.
ACCESSION #
16478272

 

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