TITLE

Comparison of the Pharmacokinetic and Pharmacodynamic Properties of Procainamide and N-Acetylprocainamide

AUTHOR(S)
Atkinson Jr., Arthur J.; Ruo, Tsuen Ih; Piergies, Antoni A.
PUB. DATE
July 1988
SOURCE
Angiology;Jul1988 Part 2, Vol. 39 Issue 7, p655
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Although procainamide (PA) has been widely used to treat patients with both ventricular and supraventricular arrhythmias since 1951, more than twenty years elapsed be- fore N-acetylprocainamide (NAPA) was identified as a major PA metabolite and shown in PA-treated patients to have plasma concentrations generally equaling or being 2 to 3 times greater than those of the parent drug. Numerous investigations have been conducted since then to characterize the pharmacokinetics and pharmacodynamics of NAPA and to compare these properties with those of PA. Salient differences have been that the elimination half-life of NAPA is 25 times that of! PA, even when reanal function is normal; that NAPA has a spectrum of electrophysiologic action that differs from PA in that NAPA only prolongs action potential duration; and that NAPA is less likely than PA to cause a syndrome resembling systemic lupus erythematosus. Although these properties have provided an impetus for the development of NAPA as an antiarrhythmic drug in its own right, emphasis is placed in this review on the implications of these findings for individualizing PA therapy.
ACCESSION #
16475409

 

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