Altered in Vitro Hemostasis, Clotting, and Thrombolysis After Oral Nifedipine in Normal Volunteers

Rademaker, Marius; Meyrick-Thomas, Richard H.; Kirby, John D. T.; Kovacs, Iren B.
August 1988
Angiology;Aug1988, Vol. 39 Issue 8, p747
Academic Journal
In this study the authors used the Haemostatometer, a new instrument to monitor the pattern of hemostatic plug formation that occurs in holes in polyethylene tubing through which nonanticoagulated blood is flowing under standard conditions. The pattern and speed of blood coagulation, subsequent to hemostasis, was also monitored. Simultaneously, the time until expulsion of hemostatic plugs formed was measured and considered as spontaneous thrombolysis time (STT). In 10 healthy volunteers, blood samples were drawn and tested before and ninety minutes after administration of 10 mg oral nifedipine. After nifedipine, the initial phase of primary hemostasis was delayed (p < 0.05), the clotting time lengthened (p < 0.01), and the STT shortened (p < 0.01). The authors conclude that the effect of nifedipine on hemostasis and thrombolysis could contribute to its therapeutic efficacy.


Related Articles

  • Containing a Clot in the Mid-Basilar Artery Using a Self-Expandable Stent to Prevent Distal Clot Migration during Intra-Arterial Thrombolysis. KIM, S. M.; LEE, D. H.; CHOI, J. W.; CHOI, B. S.; KWON, S. U.; JEONG, K. S.; SUH, D. C. // Interventional Neuroradiology;2009, Vol. 15 Issue 2, p215 

    During local intra-arterial thrombolysis (LIT), management of the secondary embolization of a fragmented or dislodged clot can be cumbersome. The fate could be dismal if without pursuit and lysis of the migrated clot. Recently, we successfully managed a patient with acute ischemia due to a large...

  • thrombolytic (Major drug group).  // Royal Society of Medicine: Medicines;2002, p532 

    This article states that thrombolytic drugs break up or dissolve thrombi or blood clots.

  • Compression of Vein Graft by Hematoma During Fibrinolytic Therapy Simulating Intrinsic Venous Stricture--A Case Report. Sprayregen, Seymour; Bakal, Curtis W.; Cynamon, Jacob // Angiology;Jan1993 Supplement, Vol. 44, p81 

    Narrowing of a vein graft at an area of perigraft extravasation was encountered during fibrinolytic therapy for graft thrombosis. With cessation of fibrinolytic therapy, extravasation ceased and the vein lumen widened. Extrinsic compression and/or spasm due to a hematoma should be included as...

  • Simultaneous Measurement of All Thrombosis Parameters from Native Human Blood: Usefulness in Monitoring Efficacy and Complications of Thrombolytic Therapy. Kovacs, Iren B.; Path, F. R. C.; Görög, Peter; Path, M.R.C. // Angiology;Oct1990, Vol. 41 Issue 10, p829 

    The sequelae of thrombus formation, both by shear forces and by collagen fiber, the subsequent coagulation, and the dislodgement of thrombi (thrombolysis) were measured from a small volume of nonanticoagulated blood sample, by a new instrument. Addition of streptokinase (SK) or tissue-type...

  • Implicit bias among physicians and its prediction of thrombolysis decisions for black and white patients. Green, Alexander R.; Carney, Dana R.; Pallin, Daniel J.; Ngo, Long H.; Raymond, Kristal L.; Lezzoni, Lisa I.; Banaji, Mahzarin R.; Iezzoni, Lisa I // JGIM: Journal of General Internal Medicine;Sep2007, Vol. 22 Issue 9, p1231 

    Context: Studies documenting racial/ethnic disparities in health care frequently implicate physicians' unconscious biases. No study to date has measured physicians' unconscious racial bias to test whether this predicts physicians' clinical decisions.Objective: To test...

  • THROMBOTEST. Vigran, I. Myron // Angiology;Oct1963, Vol. 14 Issue 10, p518 

    A simplified method for using the thrombotest has been described. This method consists of the use of a small portable instrument providing a constant temperature. Microquantities of whole blood are used, thus obviating the need for expensive and cumbersome equipment such as a centrifuge and...

  • Study sheds light on the 'Lazarus phenomenon'.  // Formulary;Mar2007, Vol. 42 Issue 3, p194 

    The article examines the intra-arterial administration of thrombolytic therapy. It demonstrated a significant and immediate clinical improvement in about one-fourth of patients with acute ischemic stroke. In this context, the author mentioned factors associated with the Lazarus phenomenon are a...

  • Thrombolysis for Pulmonary Embolism and Risk of All-Cause Mortality, Major Bleeding, and Intracranial Hemorrhage. Chatterjee, Saurav; Chakraborty, Anasua; Weinberg, Ido; Kadakia, Mitul; Wilensky, Robert L.; Sardar, Partha; Kumbhani, Dharam J.; Mukherjee, Debabrata; Jaff, Michael R.; Giri, Jay // JAMA: Journal of the American Medical Association;6/18/2014, Vol. 311 Issue 23, p2414 

    IMPORTANCE Thrombolytic therapy may be beneficial in the treatment of some patients with pulmonary embolism. To date, no analysis has had adequate statistical power to determine whether thrombolytic therapy is associated with improved survival, compared with conventional anticoagulation....

  • Thrombus removal with a temporary vena caval filter in patients with acute proximal deep vein thrombosis. Noguchi, Manabu; Eishi, Kiyoyuki; Sakamoto, Ichiro; Nakamura, Satoru; Yamachika, Shiro; Hazama, Shiro; Iwamatsu, Miyoko; Hisada, Yoichi; Izumi, Kenta; Tanigawa, Kazuyoshi // Heart & Vessels;Sep2003, Vol. 18 Issue 4, p197 

    Between September 1999 and January 2001 we performed thrombus removal with the use of a temporary vena caval filter in 11 patients who had acute iliofemoral venous thrombosis. To facilitate thrombus removal, 5 patients initially received catheter-directed thrombolytic therapy (thrombolysis...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics