Antithrombotic Potential of Pentoxifylline A Hemorheologically Active Drug

Schröer, Reiner H.
June 1985
Angiology;Jun1985, Vol. 36 Issue 6, p387
Academic Journal
An up-dated synopsis is given on the antithrombotic potential of pentoxifyl- line. Pentoxifylline enhances the PGI&sub2; release from the vascular wall and causes increasing platelet sensitivity to antiaggregating prostaglandins. By its PDE inhibiting effect pentoxifylline in high doses can also enhance PGI&sub2;-stimulated cAMP synthesis. These platelet aggregation inhibiting effects in combination with increases in fibrinolytic activity under pentoxifylline administration are suggested to be the main determinants of the compound's antithrombotic properties as evident from investigations in different animal models of thrombosis: Intravascular thrombus formation upon stimulation by both iontophoretically introduced ADP or laser injury of endothelium in the hamster cheek pouch and in the rat mesentery, respectively, was significantly reduced under pentoxifyl- line. Clinically these findings are corroborated by the regress of platelet aggregability, reduction in fibrinogen, increase in AT Ill and decrease in antiplasmin activity under treatment with pentoxifylline.


Related Articles

  • Effect of Pentoxifylline on the Flow of Polymorphonuclear Leukocytes Through a Model Capillary. Armstrong Jr., Michael; Needham, David; Hatchell, Diane Lillian; Nunn, Rashmi Saxena // Angiology;Apr1990, Vol. 41 Issue 4, p253 

    Pentoxifylline is a methylxanthine derivative used to increase blood flow in peripheral atherosclerosis. Pentoxifylline is known to increase whole blood filtration rate, and recent evidence suggests that pentoxifylline increases the filtration rate of polymorphonuclear leukocytes (PMNs). The...

  • The intraoperative effect of pentoxifylline on the inflammatory process and leukocytes in cardiac surgery patients undergoing cardiopulmonary bypass. Ça&gcaron;lι, Kerim; Ulaş, Mahmut Mustafa; Özιşιk, Kanat; Kale, Arzum; Bakuy, Vedat; Emir, Mustafa; Balcι, Mustafa; Topbaş, Murat; Şener, Erol; Taşdemir, O&gcaron;uz // Perfusion;Jan2005, Vol. 20 Issue 1, p45 

    Background: Inflammation plays a pivotal role in the pathogenesis of organ dysfunction after cardiopulmonary bypass (CPB). The aim of this study was to investigate whether pentoxifylline (PTX) has effects on the inflammatory process and leukocytes in cardiac surgery patients undergoing CPB....

  • Pentoxifylline in the Treatment of Vascular Impotence--Case Reports. Allenby, Kent S.; Burris, James F.; Mroczek, William J. // Angiology;May1991, Vol. 42 Issue 5, p418 

    Vascular impotence is a common medical problem for which available therapies are limited. Three impotent patients observed in the authors' practice who were receiving pentoxifylline for treatment of claudication of the lower extremities spontaneously reported improved sexual function. A...

  • Synthesis and rheological activity of new 1,2,4-triazole derivatives. Klen, E.; Khaliullin, F.; Spasov, A.; Makarova, N.; Bagautdinova, L.; Naumenko, L. // Pharmaceutical Chemistry Journal;Sep2008, Vol. 42 Issue 9, p510 

    Reactions of 3,5-dibromo-1,2,4-triazoles containing thietane or thietane-1,1-dioxide with thioglycolic acid yielded 2-[1-(thietanyl-3)-or 2-[1-(1,1-dioxothietanyl-3)-3-bromo-1,2,4-triazolyl-5-thio]acetic acids. Their salts have also been synthesized via reactions with amines and alkalis....

  • Doppler Ultrasonography of the Vertebrobasilar Circulation in Patients with Sudden Sensorineural Hearing Loss. Grgić, Marko; Petric, Vlado; Pastorĉić^Grgić, Marija; Demarin, Vida; Pegan, Boris // Journal of Otolaryngology;Jan/Feb2005, Vol. 34 Issue 1, p51 

    Background: The etiology of sudden sensorineural hearing loss (SSNHL) is still unclear and is most probably diverse. Objective: To determine the relationship between vertebrobasilar circulation and hearing in patients with SSNHL treated with pentoxifylline. Design: Case-control study of 32...

  • The effect of pentoxifylline on oxidative stress in CO2 pneumoperitoneum. Dinckan, Ayhan; Sahin, Emel; Ogus, Mehmet; Emek, Kemal; Gumuslu, Saadet // Surgical Endoscopy;Mar2009, Vol. 23 Issue 3, p534 

    Carbon dioxide (CO2) pneumoperitoneum induces peritoneal oxidative stress. This experimental, randomized, controlled study was designed to investigate the effect of pentoxifylline on oxidative stress induced by CO2 pneumoperitoneum. For this study, 36 Swiss albino rats were randomized into three...

  • Preventive Effect of Pentoxifylline on Acute Radiation Damage via Antioxidant and Anti-inflammatory Pathways. Hepgül, Gülçin; Tanrıkulu, Sevda; Ünalp, Haluk Recai; Akguner, Taner; Erbil, Yeşim; Olgaç, Vakur; Ademoğlu, Evin // Digestive Diseases & Sciences;Mar2010, Vol. 55 Issue 3, p617 

    Purpose The aim of the present study was to investigate whether pentoxifylline (PTX) treatment could protect against induced acute radiation enteritis. Method Rats received 100 mg/kg/day PTX for 7 days before irradiation and continued on treatment for 3 days after irradiation. The intestinal...

  • Platelet Resistance to Prostacyclin. Enhancement of the Antiaggregatory Effect of Prostacyclin by Pentoxifylline. Manrique, R. V.; Manrique, V. // Angiology;Feb1987 Part 1, Vol. 38 Issue 2, p101 

    With regard to existence of high prostacyclin (PGI2) levels during atheromatosis and thrombus formation, resistance of platelets to prostacyclin and its analogues seems to play an important pathophysiologic key role for the clarify- big of vasoocclusive phenomena. Platelet resistance to...

  • Failure of Pentoxifylline for End-stage Peripheral Vascular Disease. Loyd, Robert G.; Prian, Gregory W.; Gomez, Henry; Laub, James; Mertz, George H. // Angiology;Apr1987, Vol. 38 Issue 4, p304 

    In this trial of pentoxifylline, 15 patients with end-stage peripheral vascular disease had symptoms severe enough to warrant operation, but surgery was contraindicated because of anatomically noncorrectable disease, serious medical problems, or refusal. Their mean age was sixty-six years. Each...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics