Krantz, John C.
July 1955
American Journal of Gastroenterology;Jul1955, Vol. 24 Issue 1, p31
Academic Journal
Napoleon once declared, "Dyspepsia is the end of all things, kingdoms, expeditions and the kings." Dr. George Grile spoke of peptic ulcer as "the wound stripe of civilization". Indeed since this malady and its sequelae involve nearly 10,000,000 Americans, the importance of this problem which we face in producing better therapeutic agents cannot be over-estimated. Fundamental knowledge has been increased, new antispasmodic agents are now playing a major role in making the ulcer patient's life more useful and enjoyable. The outlook for the future is bright as we begin to interpret motility and the antispasmodic action of drugs at an enzyme and even at a molecular level. The search is exciting and the stakes are high, for as Charles Darwin once wrote to his friend Hooker, "Adios, my dear Hooker; do be wise and good, and be careful of your stomach, within which, as I know full well, lie intellect, conscience, temper, and the affections."


Related Articles

  • Peptic Ulcer Disease: What You Need to Know. Garber, Boris // Clinician Reviews;Feb2009, Vol. 19 Issue 2, p28 

    The article presents questions and answers related to peptic ulcer disease (PUD) including the clinical description and definition of PUD, who are at risk for PUD and the appropriate treatment setting for patients with dyspepsia.

  • An evidence-based approach the management of uninvestigated dyspepsia in the era of Helicobacter pylori. Veldhuyzen van Zanten, Sander J.O.; Flook, Nigel; Chiba, Naoki; Armstrong, David; Barkun, Alan; Bradette, Marc; Thomson, Alan; Bursey, Ford; Blackshaw, Patricia; Frail, Dawn; Sinclair, Paul // CMAJ: Canadian Medical Association Journal Supplement;6/13/2000 Dyspepsia, Vol. 162 Issue 12, pS3 

    AbstractObjectives: To provide Canadian primary care physicians with an evidence-based clinical management tool, including diagnostic and treatment recommendations, for patients who present with uninvestigated dyspepsia.Recommendations: The management tool has 5 key decision steps addressing the...

  • Comparison of gastrointestinal symptoms and psychological factors of functional dyspepsia to peptic ulcer or panic disorder patients. Tominaga, K.; Higuchi, K.; Iketani, T.; Ochi, M.; Kadouchi, K.; Tanigawa, T.; Shiba, M.; Watanabe, T.; Fujiwara, Y.; Oshitani, N.; Nagata, T.; Kiriike, N.; Arakawa, T. // Inflammopharmacology;Apr2007, Vol. 15 Issue 2, p84 

    Symptoms of functional dyspepsia (FD) may look like those of peptic ulcers or panic disorders. But, there is no comparative data between the symptoms of peptic ulcers or panic disorders. To evaluate general symptoms, we used the previously validated questionnaires: 1. the Gastrointestinal...

  • Endoscopic Findings and the Prevalence of Helicobacter Pylori in Dyspeptic Monks at the Priest Hospital. Kasemthamakhun, Somkiat; Chaiyarerk, Pratana // Thai Journal of Surgery;Apr-Jun2012, Vol. 33 Issue 2, p52 

    A descriptive retrospective study was carried out in 312 monks presented to the Priest Hospital with upper abdominal pain and underwent upper gastrointestinal endoscopy and tissue sampling for H. pylori by the rapid urease test during March 1, 2008 and February 28, 2011. The average age was 62 +...

  • The causes of heartburn. Hashmi, Taqi // GP: General Practitioner;11/28/2008, p31 

    The article presents the common diagnoses of a variety of gastrointestinal (GI) disorders that are associated with heartburn. It tells that when patients with symptoms of heartburn or dyspepsia undergo endoscopic investigation, their cases are classified as oesophagitis Gord, peptic ulcer or...

  • Upper gastrointestinal endoscopic findings and prevalence of Helicobacter pylori infection among adult patients with dyspepsia in northern Tanzania. AYANA, SEGNI M.; SWAI, BIRGITTA; MARO, VENANCE P.; KIBIKI, GIBSON S. // Tanzania Journal of Health Research;Jan2014, Vol. 16 Issue 1, p1 

    Dyspepsia is a common presenting complaint of various upper gastrointestinal disorders. The symptoms of causes of dyspepsia often overlap and this makes etiological diagnosis difficult. Endoscopy is the ideal procedure for identifying organic diseases of the foregut. Helicobacter pylori...

  • Congenital Double Pylorus. Naidoo, Ruvashni; Singh, Bhugwan // Case Reports in Gastrointestinal Medicine;2012, p1 

    The double pylorus is an uncommon finding and maybe congenital due to gastrointestinal duplication abnormality or more commonly secondary to peptic ulcer disease. The case we present is an elderly patient with mild dyspeptic symptoms who had an upper endoscopy as part of her investigative...

  • Jasonia Glutinosa DC. Zumeta, Nelida Sorrosal // Medicina Naturista;jul-dic2012, Vol. 6 Issue 2, p102 

    It is difficult to know when intake of Jasonia glutinosa became popular because there aren't too much historic sources that talks about daily life in villages. Its use was not recorded by the most important botanical authors from 16th to 18th century. It is not excluded that Jasonia glutinosa...

  • Peptic Ulcer Heterogeneity and Clinical Implications. McCarthy, Denis M. // Annals of Internal Medicine;Oct81, Vol. 95 Issue 4, p507 

    Editorial. Comments on the heterogeneity and clinical implications of peptic ulcer. Observations on the heterogeneity of the ulcer-prone population; Efforts of physicians to develop a successful outcome of therapy in individual patients; Environmental factors that influence peptic ulcer.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics