Prostanoid DP receptor polymorphisms may cause changes in susceptibility to asthma

ys-picard, C/.
March 2005
Thorax;Mar2005, Vol. 60 Issue 3, p248
Academic Journal
The article reports that prostaglandins have been implicated in the pathophysiology of asthma. The prostaglandin receptor is expressed on the surface of airway eosinophils and mast cells. This group has studied the gene for the prostanoid DP receptor and its relationship with the asthma phenotype. Screening revealed four new single nucleotide polymorphisms (SNPs) in addition to the two previously reported SNPs in the areas of the gene promoter region that bind transcription factors. The frequencies of the four most common SNPs were determined by restriction fragment length polymorphism analysis in patients with mild to moderate asthma and controls. Genotypic analysis showed an increased risk of asthma associated with the T-549C SNP for white and black ethnic groups.


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