Structural changes to airway smooth muscle in cystic fibrosis

Hays, S. R.; Ferrando, R. E.; Carter, R.; Wong, H. H.; Woodruff, P. G.
March 2005
Thorax;Mar2005, Vol. 60 Issue 3, p226
Academic Journal
journal article
Background: Chronic airway obstruction is characteristic of cystic fibrosis (CF) but there are few studies of airway smooth muscle remodelling in CF.Methods: Airway smooth muscle content and mean airway smooth muscle cell size were measured by applying design-based stereology to bronchoscopic biopsy specimens obtained from seven subjects with CF and 15 healthy controls.Results: The smooth muscle content increased by 63% in subjects with CF (mean (SD) 0.173 (0.08) v 0.106 (0.042) mm(3) smooth muscle/mm(3) submucosa, mean difference -0.067; 95% CI -0.12 to -0.013, p = 0.017) but there was no increase in mean cell size (2705 (351) v 2654 (757) microm(3), mean difference -51; 95% CI -687 to 585, p = 0.87).Conclusions: These findings indicate hyperplasia of airway smooth muscle cells without hypertrophy and suggest that accumulation of airway smooth muscle cells may contribute to airway narrowing and bronchial hyperresponsiveness in CF.


Related Articles

  • The 1996 Albert Lasker Medical Research Awards. The discovery of endothelium-derived relaxing factor and its importance in the identification of nitric oxide. Furchgott, R F // JAMA: Journal of the American Medical Association;10/9/96, Vol. 276 Issue 14, p1186 

    The discovery of endothelium-derived relaxing factor (EDRF) and its importance in the identification of nitric oxide (NO) originated with studies using rabbit aorta to examine drug-receptor interactions in vascular smooth muscle. Smooth muscle relaxation by acetylcholine and a number of other...

  • Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. Phillips, Roderick J.; Burdick, Marie O.; Hong, Kurt; Lutz, Mann A.; Murray, Lynne A.; Ying Ying Xue; Beiperio, John A.; Keane, Michael P.; Strieter, Robert M.; Burdick, Marie D; Lutz, Marin A; Xue, Ying Ying; Belperio, John A // Journal of Clinical Investigation;Aug2004, Vol. 114 Issue 3, p438 

    Previous reports have identified a circulating pool of CD45(+) collagen I(+) CXCR4(+) (CD45(+)Col I(+)CXCR4(+)) cells, termed fibrocytes, that traffic to areas of fibrosis. No studies have demonstrated that these cells actually contribute to fibrosis, however. Pulmonary fibrosis was originally...

  • Tracheal reaction to three different intraluminal stents in an animal model of tracheomalacia. Weinberg, Mark; Sandbank, Judith; Flumenblit, Yoseph; Klin, Baruch; Vinograd, Itzhak // Journal of Laparoendoscopic & Advanced Surgical Techniques;Jun2005, Vol. 15 Issue 3, p333 

    Three different internal airway stents were studied in an animal model of tracheomalacia: the Palmaz stent (Johnson & Johnson, Warren, New Jersey) and the NIR stent (Medinol Ltd., Tel Aviv, Israel)--both made of stainless steel in the form of tubular mesh--and the Nitinol stent, made of...

  • Abnormal passive chloride absorption in cystic fibrosis jejunum functionally opposes the classic chloride secretory defect. Russo, Michael A.; Hogenauer, Christoph; Coates Jr., Stephen W.; Santa Ana, Carol A.; Porter, Jack L.; Rosenblatt, Randall L.; Emmett, Michael; Fordtran, John S.; Coates, Stephen W Jr // Journal of Clinical Investigation;7/1/2003, Vol. 112 Issue 1, p118 

    Due to genetic defects in apical membrane chloride channels, the cystic fibrosis (CF) intestine does not secrete chloride normally. Depressed chloride secretion leaves CF intestinal absorptive processes unopposed, which results in net fluid hyperabsorption, dehydration of intestinal contents,...

  • Mucus clearance as a primary innate defense mechanism for mammalian airways. Knowles, Michael R.; Boucher, Richard C. // Journal of Clinical Investigation;3/1/2002, Vol. 109 Issue 5, p571 

    Discusses the aspects of mucus clearance system as a defense mechanism for mammalian airways. Microanatomy of airway surface; Physiology of mucus clearance from the lung; Genetic diseases associated with abnormal mucus clearance.

  • Greek hyperinsulinemic women, with or without polycystic ovary syndrome, display altered inositols metabolism. Baillargeon, Jean-Patrice; Nestler, John E; Ostlund, Richard E; Apridonidze, Teimuraz; Diamanti-Kandarakis, Evanthia // Human Reproduction;Jun2008, Vol. 23 Issue 6, p1439 

    Unlabelled: BACKGROUND We have shown that American women with polycystic ovary syndrome (PCOS) have decreased glucose-stimulated release of a putative mediator of insulin action, D-chiro-inositol (DCI)-containing inositolphosphoglycan (DCI-IPG), and increased urinary clearance of...

  • Evaluation of coxsackievirus infection in children with human immunodeficiency virus type 1-associated cardiomyopathy. Jenson, Hal B.; Gauntt, Charles J.; Easley, Kirk A.; Pitt, Jane; Lipshultz, Steven E.; McIntosh, Kenneth; Shearer, William T.; Pediatric Pulmonary and Cardiovascular Complication of HIV-1 Infection Study Group // Journal of Infectious Diseases;6/15/2002, Vol. 185 Issue 12, p1798 

    In a matched case-control study of the association between coxsackieviruses and cardiac impairment, 24 human immunodeficiency virus (HIV) type 1-infected children with cardiac impairment were compared with 24 HIV-1-infected control subjects. Serologic evidence of coxsackievirus infection was...

  • Signaling and regulation of G protein-coupled receptors in airway smooth muscle. Billington, Charlotte K.; Penn, Raymond B. // Respiratory Research;2003, Vol. 4, p2 

    Signaling through G protein-coupled receptors (GPCRs) mediates numerous airway smooth muscle (ASM) functions including contraction, growth, and "synthetic" functions that orchestrate airway inflammation and promote remodeling of airway architecture. In this review we provide a comprehensive...

  • Salicylate induces an antibiotic efflux pump in Burkholderia cepacia complex genomovar III (B. cenocepacia). Nair, Bindu M.; Cheung Jr., K-John; Griffith, Adam; Burns, Jane L.; Cheung, K-John Jr // Journal of Clinical Investigation;Feb2004, Vol. 113 Issue 3, p464 

    An antibiotic efflux gene cluster that confers resistance to chloramphenicol, trimethoprim, and ciprofioxacin has been identified in Burkbolderia cenocepacia (genomovar III), an important cystic fibrosis pathogen. Five open reading Frames have been identified in the cluster. There is apparently...


Read the Article


Sign out of this library

Other Topics