Intravenous immunoglobulin improves clinical outcome in Churg-Strauss syndrome

Hays, S. R.; Ferrando, R. E.; Carter, R.; Wong, H. H; Woodruff, P. G.
March 2005
Thorax;Mar2005, Vol. 60 Issue 3, p225
Academic Journal
The article informs that Churg-Strauss Syndrome (CSS) is a necrotizing vasculitis of medium and small sized vessels clinically characterized by asthma, eosinophilia, and systemic vasculitis associated with circulating antibodies to antineutrophil cytoplasmic antigen. The standard treatment of this condition comprises corticosteroids and, in severe cases, cytotoxic drugs. However, this treatment protocol is associated with a high relapse rate and significant drug dependent side effects. In this prospective study 18 patients with new onset CSS were evaluated and divided into two groups.


Related Articles

  • A case of Churg-Strauss syndrome complicated with bilateral central retinal artery occlusion. Ken Uchibori; Emi Shinohara; Haruhiko Furusawa; Shinichiro Tominaga; Ichiro Natsume; Minoru Ohkouchi // Chest Disease Reports;2013, Vol. 3 Issue 1, p1 

    A 56-year-old Japanese woman treated for bronchial asthma came to our hospital because of sudden vision loss of the left eye and plantar numbness of the right foot. Central retinal artery occlusion (CRAO) was diagnosed. Vision loss of the right eye also appeared, and the numbness of the right...

  • CHURG-STRAUSS SYNDROME: A RARE CASE REPORT AND A BRIEF REVIEW OF LITERATURE. Wawhal, Mahendra; Mogal, Vajed; Sonawane, Mahendra; Gole, Pratap; Kurhade, Aniket // Indian Journal of Medical Research & Pharmaceutical Sciences;Jul2015, Vol. 2 Issue 7, p17 

    Churg-Strauss syndrome (CSS) is a rare primary, non-inheritable, non-transmissible systemic disease, which occurs in patient with history of bronchial asthma. CSS is an eosinophil-associated, small vessel granulomatous vasculitis, characterized by late onset asthma, upper airway disease,...

  • Montelukast.  // Reactions Weekly;3/14/2009, Issue 1243, p35 

    The article describes the case of a 40-year-old man who acquired Churg-Strauss syndrome. The patient, who was suffering from atopic asthma, developed the said condition while undergoing treatment with montelukast. He was administered with oral corticosteroids, fluticasone and salmeterol while...

  • Omalizumab.  // Reactions Weekly;3/22/2008, Issue 1194/1195, p28 

    The article describes the case of a 45-year-old man with severe allergic asthma who developed Churg-Strauss syndrome while receiving malizumab and following tapered withdrawal of corticosteroids. He was diagnosed with eosinophilic vasculitis and was treated with high-dose corticosteroids,...

  • Churg–Strauss syndrome (CSS) in a patient receiving pranlukast. Kobayashi, Shigeto; Ishizuka, Shyugo; Tamura, Naoto; Takaya, Makiyo; Kaneda, Kazuhiko; Hashimoto, Hiroshi // Clinical Rheumatology;Dec2003, Vol. 22 Issue 6, p491 

    Pranlukast is a cysteinyl leukotriene receptor I antagonist (LTRAs) approved for treatment of asthma in Japan since 1995. Compared to other LTRAs, such as zafilukast and montelukast, only few cases with Churg-Strauss syndrome (CSS) have been reported in association with treatment with...

  • Complement is crucial in the pathogenesis of ANCA-associated vasculitis. Kallenberg, Cees G M; Heeringa, Peter // Kidney International;Jan2013, Vol. 83 Issue 1, p16 

    Renal lesions in ANCA-associated vasculitis (AAV) show an absence or paucity of immune deposits. Therefore, complement was not considered a major pathogenic factor. Data from an animal model of AAV, however, suggest involvement of the alternative pathway of complement. The paper by Gou et al....

  • CHURG-STRAUSS SYNDROME. ????, TaTjaHa; ?o43F;oB??-Ky?MaHoB??, ?paraHa; M??????, AHKa; ?apaHoc, CBeT?aHa // Vojnosanitetski Pregled: Military Medical & Pharmaceutical Journ;Mar/Apr2002, Vol. 59 Issue 2, p209 

    Churg-Strauss syndrome (CSS) is medium blood vessels vasculitis with predilection for lungs in patients with bronchial asthma, chronic eosinophilic pneumonia and positive ANCA in the sera in 55-67%. This is a case report of a 60 years old female patient with bronchial asthma, peripherial...

  • Eosinophilic Neuropathy -- Is It In Your Skin? Latov, Norman // Neurology Alert;Sep2007, Vol. 26 Issue 1, p1 

    Peripheral neuropathy is common in patients with the Churg-Strauss syndrome that present with eosinophilia, asthma, and small vessel vasculitis. Neuropathy also occurs in primary eosinophilia, in the absence of Churg-Straus syndrome, but a nerve and muscle biopsy is often required in such cases...

  • Churg-Strauss syndrome: retrospective study in Burgundian population in France in past 10 years. Vinit, ,5Julien; Muller, Géraldine; Bielefeld, Philip; Pfitzenmeyer, Pierre; Bonniaud, Philippe; Lorcerie, Bernard; Besancenot, Jean-François // Rheumatology International;May2011, Vol. 31 Issue 5, p587 

    Churg-Strauss Syndrome (SCS) is a systemic vasculitis associated with asthma and eosinophilia. The aim of our work is to describe this pathology in the Burgundian population in France. We counted from the hospitalisation data-processing summaries, the whole of the SCS hospitalised in Burgundy...


Read the Article


Sign out of this library

Other Topics