Photoallergic Skin Reaction to Ribavirin

Stryjek-Kaminska, Danuta; Ochsendorf, Falk; Röder, Claudia; Wolter, Manfred; Zeuzem, Stefan
June 1999
American Journal of Gastroenterology;Jun1999, Vol. 94 Issue 6, p1686
Academic Journal
A 65-yr-oId woman with chronic hepatitis C was treated with three million units interferon-α t.i.w. and 1000 mg ribavirin daily. At wk 16 of combination therapy the patient developed an itchy eczematous erythema, partly of urticarial character, which was almost confined to ultraviolet (UV)-exposed sites. Histopathological examination of the skin lesions was consistent with a photoallergic reaction. The minimal erythematous dose for UVA and UVB was assessed on healthy skin. After 24 h, a distinct erythema at the UVB irradiated site was found, whereas no reaction was seen with UVA provocation up to a dose of 10 J/cm². Correspondingly, determination of the absorption spectrum of ribavirin revealed maximum absorption within UVB at 282.5 nm. Ribavirin was stopped, and the cutaneous lesions and pruritus completely disappeared without subsequent hyperpigmentation. This case indicates that ribavirin is a potential photosensitizer for UVB, which may become increasingly relevant in patients with chronic hepatitis C undergoing combination therapy for 6-12 months with interferon-α and ribavirin.


Related Articles

  • Topical All-trans Retinoic Acid Does not Influence Minimal Erythema Doses for UVB Light in Normal Skin. Smit, J. V.; de Jongh, E. M. G. J.; de Jongh, G. J.; van de Kerkhof, P. C. M. // Acta Dermato-Venereologica;Jan2000, Vol. 80 Issue 1, p66 

    Evaluates the minimal erythema dose for ultraviolet B (UVB) irradiation on tropical all-trans retinoic acid pre-treated skin and untreated skin. Influence of retinoids in UV-induced skin changes; Side-effects of tropical retinoids; Degree of erythema before and after UVB irradiation.

  • Influence of UVA on the Erythematogenic and Therapeutic Effects of UVB Irradiation in Psoriasis; Photoaugmentation Effects. Boer, Jurr; Schothorst, Albert A.; Suurmond, Dick // Journal of Investigative Dermatology;Jan1981, Vol. 76 Issue 1, p56 

    The effect of repeated exposure to an additive dose of long ultraviolet (UVA) radiation on the erythemogenic and therapeutic effects of middle ultraviolet (UVB) irradiation was investigated in 8 patients with psoriasis. The surface of the backs of these patients was divided into 2 parts, 1 of...

  • Combined interferon α2b and cyclosporin A in the treatment of chronic hepatitis C: controlled trial. Inoue, Kazuaki; Sekiyama, Kazuhiko; Yamada, Masaya; Watanabe, Tsunamasa; Yasuda, Hiroshi; Yoshiba, Makoto // Journal of Gastroenterology;2003, Vol. 38 Issue 6, p567 

    Background. Only 15% to 20% of patients with chronic hepatitis C have a sustained virological response to interferon monotherapy. The aim of the present study was to compare the efficacy and safety of interferon, in combination with oral cyclosporin A, with interferon monotherapy in the...

  • Review: Interferon α-2b is effective for biochemical and virologic outcomes in acute hepatitis C virus infection. King, Paul D. // ACP Journal Club;Sep/Oct2002, Vol. 137 Issue 2, p60 

    Presents a study that investigated the effectiveness of interferon in patients with acute hepatitis C virus infection. Interferon α-2b versus no treatment in acute hepatitis C virus infection; Information on data sources and study selection; Analysis of the effect of interferon on the...

  • THERAPY IN CHRONIC HEPATITIS C: SAY GOODBYE TO THE 6-MONTH INTERFERON REGIMEN. Koff, Raymond S. // American Journal of Gastroenterology;Oct1996, Vol. 91 Issue 10, p2072 

    Presents information on chronic hepatitis C. Prevalence of the disease in the U.S.; Discussion of the interferon alpha therapy used in treating hepatitis C; Recommendations on the treatment for the disease.

  • The Effect of Methoxsalen Dose on Ultraviolet-A-Induced Erythema. Ibbotson, Sally H.; Dawe, Robert S.; Farr, Peter M. // Journal of Investigative Dermatology;May2001, Vol. 116 Issue 5, p813 

    There is considerable interindividual variation in bioavailability of Methoxsalen (8-methoxypsoralen) after ingestion of the standard dose used in photochemotherapy (psoralen plus ultraviolet A). A dose change may be used to alter the degree of photosensitivity, although there is limited...

  • Early Loss of Serum Hepatitis C Virus RNA Can Predict a Sustained Response to Interferon Therapy in Patients with Chronic Hepatitis C. Karino, Yoshiyasu; Toyota, Jouji; Sugawara, Masaaki; Higashino, Kiyoshi; Sato, Takahiro; Ohmura, Takumi; Suga, Toshihiro; Okuuchi, Yutaka; Matsushima, Takashi // American Journal of Gastroenterology;Jan1997, Vol. 92 Issue 1, p61 

    Objectives: We evaluated whether the loss of serum hepatitis C virus (HCV) RNA early in interferon (IFN) therapy would indicate a subsequent response to IFN therapy. Methods: One hundred fourteen patients with chronic hepatitis C were treated with IFN-α for 24 weeks. All patients were...

  • Efficacy of High-Dose Interferon in Combination With Ribavirin in Patients With Chronic Hepatitis C Resistant to Interferon Alone. Min, Albert D.; Jones, Jennifer L.; Esposito, Stephen; Lebovics, Edward; Jacobson, Ira M.; Klion, Franklin M.; Goldman, Ira S.; Geders, Jane M.; Tobias, Hillel; Bodian, Carol; Bodenheimer Jr., Henry C. // American Journal of Gastroenterology;Apr2001, Vol. 96 Issue 4, p1143 

    OBJECTIVE: Interferon combined with ribavirin has efficacy in the treatment of patients with chronic hepatitis C virus (HCV) infection. However, its utility in patients who have not responded to prior interferon therapy is not clear. Furthermore, the effect of using an increased dose of...

  • Factors Predicting Interferon Treatment Response in Patients With Chronic Hepatitis C: Late Viral Clearance Does Not Preclude a Sustained Response. Ebeling, Freja; Lappalainen, Maija; Vuoristo, Matti; Nuutinen, Hannu; Leino, Rauli; Karvonen, Anna-Liisa; Lehtola, Juhani; Julkunen, Risto; Pohjanpelto, Pirkko; Färkkilä, Martti // American Journal of Gastroenterology;Apr2001, Vol. 96 Issue 4, p1237 

    OBJECTIVES: Because of the suboptimal efficacy, cost, and adverse effects of interferon in chronic hepatitis C (HCV). predictors have been sought to detect patients with a good treatment response. Also, markers for determining a poor response early in the course of therapy, such as the lack of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics