Does Progesterone Fluctuation Across the Menstrual Cycle Predispose to Gastroesophageal Reflux?

Alvarez-Sánchez, Angel; Rey, Enrique; Achem, Sami R.; Díaz-Rubio, Manuel
June 1999
American Journal of Gastroenterology;Jun1999, Vol. 94 Issue 6, p1468
Academic Journal
OBJECTIVE: Gastroesophageal reflux (GER) occurs in 30-50% of all pregnancies. The progressive rise in plasma progesterone has been suggested as a possible mediator of GER during pregnancy, it is not known whether progesterone, at physiological concentrations, has an effect on acid contact time. We sought to evaluate the relationship between progesterone concentrations, lower esophageal sphincter pressure (LESP), and acid contact time across the normal menstrual cycle. METHODS: LESP, 24-h ambulatory esophageal pH monitoring, and serum progesterone levels were determined in 19 healthy women known to have normal menstrual cycles. All tests were performed during the follicular phase (days 2-7) and the luteal phase (days 22-28) of one or two consecutive menstrual cycles. RESULTS: Despite marked oscillations in progesterone levels between the follicular phase (0.37 ± 0.3 ng/ml) and luteal phase (4.64 ± 2.92 ng/ml) we observed no significant differences in LESP (29.82 ± 9.49 vs 30.45 ± 8.56 mm Hg) or 24-h ambulatory pH levels (pH < 4) in total time (3.04 ± 0.3% vs 3.18 ± 2.51%), upright time (4.41 ± 3.54% vs 4.18 ± 3.36%), or supine time (0.77 ± 1.32% vs 1.42 ± 2.18%). CONCLUSIONS: The fluctuations in progesterone levels across the normal menstrual cycle have no significant impact on LESP and 24-h ambulatory pH parameters. Progesterone, at physiological concentrations, does not predispose to GER in healthy menstruating women.


Related Articles

  • The lower esophageal sphincter. Paterson, William G.; Zhang, Yong // Clinical & Investigative Medicine;Feb/Apr2002, Vol. 25 Issue 1/2, p47 

    Provides information on the intrinsic and extrinsic components of the lower esophageal sphincter (LES). Origin of resting LES tone; Role of LES in gastroesophageal reflux disease.

  • Endoluminal delivery of radiofrequency energy to the gastroesophageal junction in uncomplicated GERD: Efficacy and potential mechanism of action. DiBaise, John K.; Brand, Randall E.; Quigley, Eamonn M.M. // American Journal of Gastroenterology;Apr2002, Vol. 97 Issue 4, p833 

    OBJECTIVES:The endoluminal delivery of radiofrequency energy to the gastroesophageal junction has been shown to decrease symptoms of gastroesophageal reflux disease in a multicenter study. In this single-center trial, we sought to further examine its efficacy and physiological effects in...

  • Delivery of radiofrequency energy to the lower oesophageal sphincter and gastric cardia inhibits transient lower oesophageal sphincter relaxations and gastro-oesophageal reflux in patients with reflux disease. Tam, W.C.E.; Schoeman, M.N.; Zhang, Q.; Dent, J.; Rigda, R.; Utley, D.; Holloway, R.H. // Gut;Apr2003, Vol. 52 Issue 4, p479 

    Background and aims: Radiofrequency energy (RFe) treatment to the lower oesophageal sphincter (LOS) and gastric cardia is a new luminally delivered therapy proposed as an alternative treatment for gastro-oesophageal reflux disease (GORD). However, it is unclear how RFe achieves its antireflux...

  • ANTAGONIST: Laparoscopic fundoplication is the treatment of choice for gastro-oesophageal reflux disease. Glamiche, J.P. // Gut;Oct2002, Vol. 51 Issue 4, p472 

    Discusses the effectiveness of laparoscopic fundoplication for the treatment of gastroesophageal reflux disease (GORD). Efficacy of amtireflux surgery as compared to medical therapy; Side effects; Long-term safety; Risk of malignancies during long term treatment of GORD.

  • Mechanisms of gastro-oesophageal reflux in preterm and term infants with reflux disease. Omari, T.I.; Barnett, C.P.; Benninga, M.A.; Lontis, R.; Goodchild, L.; Haslam, R.R.; Dent, J.; Davidson, G.P. // Gut;Oct2002, Vol. 51 Issue 4, p475 

    Background: Transient lower oesophageal sphincter relaxation (TLOSR) is the predominant mechanism of gastro-oesophageal reflux (GOR) in healthy infants but the mechanisms of GOR in infants with GOR disease (GORD) are poorly understood. Aims: To measure the occurrence of TLOSR, GOR, and gastric...

  • Effect of body position on lower esophageal sphincter pressure. Iwakiri, Katsuhiko; Sugiura, Toshiaki; Kotoyori, Makoto; Yamada, Hisagi; Hayashi, Yoshinori; Nakagawa, Yoshiya; Kawakami, Akihiko; Kobayashi, Masafumi // Journal of Gastroenterology;1999, Vol. 34 Issue 3, p305 

    Abstract: This study examined the effect of body position on lower esophageal sphincter (LES) pressure. In 36 healthy subjects and 31 patients with reflux esophagitis, LES and intragastric pressures were measured with subjects in the supine and sitting positions by the intraluminal...

  • Positioning of the ph-Probe by Manometry or Radiography for monitoring of the esophagus. Aksglæde, K.; Thommesen, P. // Acta Radiologica;Jul2003, Vol. 44 Issue 4, p360 

    Abstract Purpose: To correlate gastroesophageal reflux (GER), demonstrated by radiography using bread and barium, with 24-h pH monitoring in the esophagus, with the pH-probe positioned by manometry or radiology. Material and Methods: In all, 146 patients, 41 females and 105 males, with a median...

  • Belching: dyspepsia or gastroesophageal reflux disease? Lin, Mona; Triadafilopoulos, George // American Journal of Gastroenterology;Oct2003, Vol. 98 Issue 10, p2139 

    : ObjectivesEructation (belching) is a common symptom seen in clinical practice. Because either belching or heartburn may result from transient lower esophageal sphincter relaxations, it has been proposed that belching may be a manifestation of gastroesophageal reflux disease (GERD). In this...

  • Marked asymmetry of LES: Important element of LES barrier in subsets of patients with reflux... Sluss, K.F.; Donahue, P.E. // American Surgeon;Jul95, Vol. 61 Issue 7, p573 

    Determines whether computerized axial manometry (CAM) can explain the function of the lower esophageal sphincter (LES) in health and disease. Comparison of CAM data of gastroesophageal reflux disease (GERD) patients with normal study volunteers; Basis of reflux diagnosis on endoscopic...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics