Kleckner Jr., Martin S.
November 1959
American Journal of Gastroenterology;Nov1959, Vol. 32 Issue 5, p609
Academic Journal
The clinical effectiveness of a new anticholinergic agent, Cantil, an analogue of 3 hydroxy-piperidine was determined in various intestinal disturbances, particularly the irritable bowel syndrome and idiopathic chronic ulcerative colitis by a long-term double-blind, controlled investigation. When evaluated on the basis of relief of abdominal pain, abnormal bowel action, usually diarrhea, and gaseous distress, Cantil was found to be therapeutically more efficacious than atropine or a placebo and to produce few undesirable side-effects. When studied by basal secretory gastric analysis, serial intestinal roentgenograms, and balloon-kymographic technic, this agent was demonstrated to exert marked inhibition of intestinal motor activity and to have a mild gastric antisecretory property. This study was also conducted among patients with intestinal disturbances in a psychiatric clinic. All three agents produced a marked incidence of side-effects and the placebo relieved intestinal complaints. Cantil appeared more effective in passive, aggressive anxiety type of psychoneurosis with intestinal disturbances.


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