Freed, S. Charles; Proctor, John H.
January 1967
Angiology;Jan1967, Vol. 18 Issue 1, p62
Academic Journal
Endotoxin administration to rats markedly depresses blood pressure in association with a dilution of potassium in artery muscle. Pretreatment with prednisolone prevents the hemodynamic and electrolyte changes. In rats subjected to endotoxin, repeated injections of l-norepinephrine elicits normal pressor responses (phasic contraction), followed by further depression of the blood pressure to shock levels, an effect prevented by prednisolone. It is suggested that tonal mechanisms influenced by muscle potassium concentration are responsible for the blood pressure changes.


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