Dietzman, Ronald H.; Ersek, Robert A.; Bloch, Jack M.; Lillehei, Richard C.
December 1969
Angiology;Dec1969, Vol. 20 Issue 11, p691
Academic Journal
Gram-negative septic shock in man of the high-output, low-resistance variety appears to be related to the opening of arteriovenous shunts in inflamed areas such as lung or peritoneum. Despite these features, an intense degree of peripheral vasoconstriction and reduced tissue perfusion due to increased sympathetic activity is present similar to that already noted in the low output-high resistance variety of septic shock. Consequently, therapy should be directed at reduction of this peripheral vasoconstriction and improvement of tissue perfusion in all instances of septic shock. A combination of volume replacement-vasodilators-positive inotropic agents has proven effective in resuscitating patients from septic shock and increasing survival.


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