Effect of Digitalis on Diminished Baroreceptor Sensitivity in Diabetics

Cokkinos, Dennis V.; Haralambakis, Aris G.; Thalassinos, Nicholas C.; Heimonas, Elias T.; Demopoulos, John N.; Voridis, Eutychios M.; Gardikas, Constantine D.
August 1979
Angiology;Aug1979, Vol. 30 Issue 8, p549
Academic Journal
The baroreceptor sensitivity was estimated in 50 normal controls (Group A) and in 50 diabetics of comparable age (Group B). The technique used was infusion of angiotensin (0.5 �g/min) and measurement of the bradycardic response resulting from the increase of blood pressure. The slope was used as an index of baroreceptor sensitivity. Diabetics had significantly lower baroreceptor sensitivity and a higher resting heart rate. Sensitivity decreased with age in both groups. The reproducibility of the method was excellent. Deslanoside-C (0.8 mg) significantly increased the baroreceptor sensitivity in 11 normal controls and 9 diabetics. Very low sensitivity was found in 26 diabetics who had no evidence of orthostatic hypotension, neuropathy, or retinopathy. However all 17 patients with the above findings had very low sensitivity.


Related Articles

  • Strengthening the heartbeat.  // British Medical Journal;7/21/1979, Vol. 2 Issue 6183, p160 

    Examines the use of digitalis in strengthening the force of heartbeat. Decline in value of digitalis in chronic heart failure in comparison to potent loop diuretics; Development of dobutamine through molecular manipulation of isoprenaline; Stimulation of cardiac beta-adrenoceptors.

  • Assessment of drug effects on blood pressure and pulse pressure using clinic, home and ambulatory measurements. Stergiou, GS; Efstathiou, SP; Skeva, II; Baibas, NM; Kalkana, CB; Mountokalakis, TD // Journal of Human Hypertension;Oct2002, Vol. 16 Issue 10, p729 

    This study investigated the differences in the effect of an angiotensin converting enzyme inhibitor (ACEI) compared with an angiotensin receptor blocker (ARB) on blood pressure (BP) and pulse pressure (PP) measured in the clinic (CBP and CPP, respectively), at home (HBP, HPP) and with ambulatory...

  • Can we study the baroreflex mechanisms with other variables than blood pressure and heart rate? Esta�ol, Bruno // Archivos de Cardiolog�a de M�xico;abr-jun2012, Vol. 82 Issue 2, p91 

    No abstract available.

  • Phase and frequency locking of 0.1-Hz oscillations in heart rate and baroreflex control of blood pressure by breathing of linearly varying frequency as determined in healthy subjects. Karavaev, A.; Kiselev, A.; Gridnev, V.; Borovkova, E.; Prokhorov, M.; Posnenkova, O.; Ponomarenko, V.; Bezruchko, B.; Shvartz, V. // Human Physiology;Jul2013, Vol. 39 Issue 4, p416 

    Functional interaction was studied between the subsystems that ensure autonomic control of the heart rate (HR) and blood pressure (BP) and give rise to 0.1-Hz oscillations in R-R intervals (RRI) and photoplethysmogram (PPG). Twenty-five recordings were obtained from 18- to 32-year-old healthy...

  • Arterial baroreflex control of muscle sympathetic nerve activity under orthostatic stress in humans. Ichinose, Masashi; Nishiyasu, Takeshi // Frontiers in Physiology;Jul2012, Vol. 3, preceding p1 

    The mechanisms by which blood pressure is maintained against the orthostatic stress caused by gravity's effect on the fluid distribution within the body are important issues in physiology, especially in humans who usually adopt an upright posture. Peripheral vasoconstriction and increased heart...

  • Effect of Barodenervation on Cardiovascular Responses Elicited from the Hypothalamic Arcuate Nucleus of the Rat. Kawabe, Tetsuya; Kawabe, Kazumi; Sapru, Hreday N. // PLoS ONE;Dec2012, Vol. 7 Issue 12, p1 

    We have previously reported that chemical stimulation of the hypothalamic arcuate nucleus (ARCN) in the rat elicited increases as well as decreases in blood pressure (BP) and sympathetic nerve activity (SNA). The type of response elicited from the ARCN (i.e., increase or decrease in BP and SNA)...

  • Two Cases of Bezold-Jarisch Reflex. Shah, Sachin P.; Waxman, Sergio // Texas Heart Institute Journal;2013, Vol. 40 Issue 4, p484 

    The Bezold-Jarisch reflex, a well-described phenomenon, occurs upon the stimulation of intracardiac mechanoreceptors and is mediated by vagal afferent nerve fibers. Several factors can sensitize the cardiovascular system to develop this reflex, including acute myocardial ischemia, natriuretic...

  • Use of Intravenous Amiodarone for Postoperative Junctional Ectopic Tachycardia in Children. Laird, W.P.; Snyder, C.S.; Kertesz, N.J.; Friedman, R.A.; Miller, D.; Fenrich, A.L. // Pediatric Cardiology;Mar2003, Vol. 24 Issue 2, p133 

    To assess the efficacy and safety of intravenous (IV) amiodarone for the treatment of postoperative junctional ectopic tachycardia (JET) in children, we retrospectively reviewed 11 patients treated with IV amiodarone for JET between 1/92 and 2/00. Data included heart rate and hemodynamics pre-...

  • Patents in the Diagnosis and Therapy of Neurocardiogenic Syncope. Kostopoulou, Anna; Livanis, Efthimios G.; Voudris, Vassilis // Recent Patents on Cardiovascular Drug Discovery;Jan2009, Vol. 4 Issue 1, p67 

    Neurocardiogenic syncope is one of the most common types of syncope, characterized by arterial vasodilatation with or without bradycardia. The regulation of blood pressure and heart rate is the result of a complex reaction between the central and peripheral nervous system with the circulatory...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics