The Rheological Effects of Cinnarizine and Flunarizine in Normal and Pathologic Conditions

De Cree, J.; De Cock, W.; Geukens, H.; De Clerck, F.; Beerens, M.; Verhaegen, H.
August 1979
Angiology;Aug1979, Vol. 30 Issue 8, p505
Academic Journal
In six separate studies comprising 68 subjects, assessments were made of whole blood viscosity at rest and under maximal ischemic exercise of the arm, and of red blood cell (RBC) deformability under normal and hyperosmolar conditions. Patients with vascular diseases, including intermittent claudication, postmyocardial infarction, diabetes, and cerebral arteriosclerotic disease, had a significant increase of whole blood viscosity and a decrease of RBC deformability when compared to a normal age-matched control group. Acute and subacute treatment with cinnarizine and its difluoroderivative flunarizine in open, double-blind, and cross-over experiments significantly reverted the increased blood viscosity due to maximal ischemic exercise of the arm in normals and in patients. Flunarizine further significantly lowered the increased blood viscosity in patients with intermittent claudication. In similar experiments flunarizine significantly increased RBC deformability under hyperosmolar conditions in normal volunteers, and increased the reduced RBC deformability in patients with vascular diseases. The calcium antagonism of cinnarizine and flunarizine may well be the mechanism of action that explains both the effects on blood viscosity, via an augmented RBC deformability, and the antivasoconstrictive effects.


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