TITLE

Misoprostol and Ranitidine in the Prevention of NSAID-Induced Ulcers: A Prospective, Double-Blind, Multicenter Study

AUTHOR(S)
Raskin, Jeffrey B.; White, Richard H.; Jaszewski, Richard; Korsten, Mark A.; Schubert, Timothy T.; Fort, John G.
PUB. DATE
February 1996
SOURCE
American Journal of Gastroenterology;Feb1996, Vol. 91 Issue 2, p223
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: To compare ranitidine to misoprostol with respect to the prevention of gastric and duodenal ulcers in patients on chronic NSAID therapy. Methods: A multi-center, 8-wk, randomized, double-blind study. Eligible patients were on chronic NSAID therapy and were experiencing NSAID-related upper gastrointestinal (UGI) pain without UGI endoscopic evidence of gastric or duodenal ulcers. Patients enrolled in the study were randomized to either misoprostol 200 µg q.i.d. or ranitidine 150 mg b.i.d.. Follow-up UGI endoscopy was performed after 4 and 8 wk of treatment. Therapeutic failure was considered the development of a gastric or duodenal ulcer ≥ 0.3 cm in diameter with perceptible depth. Results: Gastric ulcers were found in only 1/180 (0.56%) patient on misoprostol and in 11/194 (5.67%) patients on ranitidine, a difference that was statistically significant (p < 0.01). Duodenal ulcer rates were similar for the ranitidine (2/185 or 1.08%) and misoprostol (2/ 181 or 1.10%) groups. Conclusion: Misoprostol is significantly more effective than ranitidine in the prevention of NSAID-induced gastric ulcers. Ranitidine was as effective as misoprostol for the prevention of NSAID-induced duodenal ulcers. Misoprostol should be used for prophylaxis against both gastric and duodenal ulceration in patients on chronic NSAID therapy.
ACCESSION #
16440136

 

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