Treatment of Proctalgia Fugax with Salbutamol Inhalation

Eckardt, Volker F.; Dodt, Oliver; Kanzler, Gerd; Bernhard, Gudrun
April 1996
American Journal of Gastroenterology;Apr1996, Vol. 91 Issue 4, p686
Academic Journal
Objectives: Although no generally effective treatment for proctalgia fugax is known, inhalation of salbutamol has been reported to shorten pain attacks in isolated cases. Methods: We conducted a randomized, double. blind, placebo-controlled, crossover trial of inhaled salbutamol in 18 patients with proctalgia fugax. The clinical effect was evaluated by recording the duration of severe pain and discomfort during acute attacks. In addition, anorectal motility recordings were analyzed for possible changes in anal resting tone, sphincter relaxation during rectal distension and in rectal compliance prior to and following administration of the two test substances. Results: Sixteen patients completed all investigations. Compared to placebo, salbutamol inhalation shortened the duration of severe pain (p = 0.019). The effect was most marked in patients having prolonged attacks. In the asymptomatic state, neither salbutamol nor placebo led to a significant change in anal resting pressure, anal relaxation during rectal distension, or rectal compliance. Salbutamol also did not alter the threshold for rectal sensation. Conclusions: Salbutamol inhalation shortens attacks of severe pain in patients with proctalgia fugax. The mechanism of this effect remains unexplained.


Related Articles

  • Welcome. Maynard, Doug // Canadian Journal of Respiratory Therapy;Autumn2005, Vol. 41 Issue 4, p4 

    The article focuses on various developments related to respiratory therapy. The Canadian Society of Respiratory Therapists (CSRT) has been moving forward with initiatives that enhance the profile of the Society for its members, as well as providing the membership with information and...

  • Respiratory Therapy in the Middle East -- Live From Beirut. Hunter, Dennis // Canadian Journal of Respiratory Therapy;Winter2004, Vol. 40 Issue 5, p5 

    Provides information on the respiratory therapy program at Maskassed General Hospital in Beirut, Lebanon. Modes of treatment used by respiratory therapist; Involvement of Fanshawe College in the development of respiratory therapy program at the hospital; Respiratory therapy training for staff.

  • Drug Cloud.  // Technology Review;Jul/Aug2000, Vol. 103 Issue 4, p20 

    Informs that Battelle Pulmonary Therapeutics is aiming to deliver inhalable drugs more efficiently with `electrohydrodynamic' or EHD, aerosol technology. Use of voltage, rather than pressure, to create a `soft cloud' of aerosolized drug; Valuable against respiratory diseases and infections.

  • Home Oxygen Therapy for Treatment of Patients with Chronic Obstructive Pulmonary Disease. Bailey, R. Eugene // American Family Physician;9/1/2004, Vol. 70 Issue 5, p864 

    Presents a clinical scenario on the practice of home oxygen therapy for the treatment of patients with chronic obstructive pulmonary disease (COPD). Patients in which continuous oxygen therapy is indicated; Modes of delivery for oxygen therapy; Interventions that have proved effective in the...

  • OIG: Inhalation drug suppliers provide few services.  // Drug Topics;10/10/2005, Vol. 149 Issue 19, p8 

    This article presents the findings of a study that covered a random sample of 480 Medicare patients and 203 suppliers in the U.S., regarding the extent of refill-reminder and other services received by Medicare beneficiaries from their inhalation drug suppliers. The study found that 60 percent...

  • Phentermine and Topiramate.  // AHFS Consumer Medication Information;Sep2017, p1 

    Phentermine and topiramate extended-release (long-acting) capsules are used to help adults who are obese or who are overweight and have weight-related medical problems to lose weight and to keep from gaining back that weight. Phentermine and topiramate extended-release capsules must be used...

  • DANTROLENE. GRIFFITH, H. WINTER // Complete Guide to Prescription & Nonprescription Drugs 2012;2011, p302 

    The article presents information on dantrolene, a muscle relaxant and antispastic drug, including its dosage, usage, adverse reactions, side effects, precautions when administering, and possible interaction with other drugs.

  • carisoprodol.  // Royal Society of Medicine: Medicines;2002, p142 

    This article presents information on the muscle relaxant carisoprodol. This drug can be used for relaxing muscles that are in spasm. It works by an action on the central nervous system. Administration is oral. It is not used in patients with porphyria.

  • ethosuximide.  // Royal Society of Medicine: Medicines;2002, p236 

    This article focuses on anticonvulsant and anti-epileptic ethosuximide. It can be used mainly to treat absence, myoclonic and some other types of seizure. Administration is oral. It should be administered with caution to patients with porphyria, kidney or liver impairment or who are pregnant or...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics