TITLE

The Acute Effects of Nifedipine on Calf and Forefoot Blood Flow in Patients with Peripheral Arterial Insufficiency

AUTHOR(S)
Lorentsen, E.; Landmark, K.
PUB. DATE
January 1983
SOURCE
Angiology;Jan1983, Vol. 34 Issue 1, p46
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The calcium-blocking agent nifedipine, which possesses vasodilating potency, was tested in 8 patients with peripheral arterial insufficiency. 10 mg sublingually significantly decreased systolic arm and ankle blood pressure. Neither blood flow nor local peripheral resistance in the calf and the forefoot at rest and the calf during postischemic reactive hyperemia changed significantly. During postischemic hyperemia in the forefoot, the drug significantly reduced peak blood flow and increased local peripheral resistance. The drug-induced reduction in forefoot peak blood flow was correlated to the fall in systolic arm and ankle blood pressure. It is suggested that nifedipine may shorten the claudication distance in patients with peripheral arterial insufficiency.
ACCESSION #
16438470

 

Related Articles

  • Microvascular Evaluation of the Effects of Nifedipine in Vascular Patients by Laser-Doppler Flowmetry. Belcaro, Giovanni; Nicholaides, Andrew N. // Angiology;Aug1989, Vol. 40 Issue 8, p689 

    Skin blood flow in the microcirculation of the distal foot was evaluated in patients with vascular disease and diabetes and compared with that in normal volunteers by use of laser-Doppler flowmetry. Resting flow (RF) and the flow on standing (SF) were measured in a room at constant temperature...

  • Effects of exercise on vasodilatory capacity in endurance- and resistance-trained men. Baynard, Tracy; Miller, Wayne C.; Fernhall, Bo // European Journal of Applied Physiology;Mar2003, Vol. 89 Issue 1, p69 

    To determine vasodilatory responsiveness we measured forearm blood flow (FBF) following reactive hyperemia (RH), prior to and following a bout of maximal aerobic exercise in endurance- (n=14) and resistance-trained men (n=10). Both groups were similar in height, body mass, and percentage body...

  • A novel endothelial function test using Doppler flow: the snuff-box technique. Kochi, Kazuhiro; Hojyo, Hiroshi; Ban, Koji; Sueda, Taijiro // Heart & Vessels;Sep2005, Vol. 20 Issue 5, p207 

    Precise measurement of Doppler estimated blood flow volume using the standard technique of flow-mediated vasodilation is not possible because the anatomic course of the brachial or radial artery goes against the principle of Doppler measurements that the insonation angle should be less than...

  • The effect of fenoldopam and dopexamine on hepatic blood flow and hepatic function following coronary artery bypass grafting with hypothermic cardiopulmonary bypass Adluri, Rajeshwara Krishna Prasad; Singh, Arvind V.; Skoyles, Julian; Robins, Adrian; Hitch, Anthony; Baker, Mya; Mitchell, Ian Moore // European Journal of Cardio-Thoracic Surgery;Jun2009, Vol. 35 Issue 6, p988 

    Abstract: Background: Hypothermic cardiopulmonary bypass is associated with low perfusion state causing a mismatch between demand and supply to various organs such as gut, kidneys and brain. The consequences are thought to be responsible for postoperative complications like systemic inflammatory...

  • Gender and nitric oxide-mediated vasodilation in humans. Dietz, N.M. // Lupus;1999, Vol. 8 Issue 5, p402 

    Background: We compared forearm vasodilator responses between females and males after administration of compounds that stimulate nitric oxide (NO) release, act as NO donors, or are NO-independent. Methods and results: We studied nine premenopausal females and nine age-matched males. Forearm...

  • Quantification of global myocardial oxygenation in humans: initial experience. McCommis, Kyle S.; O'Connor, Robert; Lesniak, Donna; Lyons, Matt; Woodard, Pamela K.; Gropler, Robert J.; Jie Zheng // Journal of Cardiovascular Magnetic Resonance (BioMed Central);2010, Vol. 12, p34 

    Purpose: To assess the feasibility of our newly developed cardiovascular magnetic resonance (CMR) methods to quantify global and/or regional myocardial oxygen consumption rate (MVO2) at rest and during pharmacologicallyinduced vasodilation in normal volunteers. Methods: A breath-hold T2...

  • Determinants of myocardial blood flow response to cold pressor testing and pharmacologic vasodilation in healthy humans. Prior, John O.; Schindler, Thomas H.; Facta, Alvaro D.; Hernandez-Pampaloni, Miguel; Campisi, Roxana; Dahlbom, Magnus; Schelbert, Heinrich R. // European Journal of Nuclear Medicine & Molecular Imaging;Jan2007, Vol. 34 Issue 1, p20 

    Response of myocardial blood flow (MBF) to sympathetic stimulation with cold is modulated by endothelium-related factors and is typically altered in the presence of coronary risk factors. Determinants of flow response to cold pressor testing (CPT) in normal volunteers at low risk for CAD remain...

  • Absence of Flow-Mediated Vasodilation in the Rabbit Femoral Artery. Clifford, P. S.; Madden, J. A.; Hamann, J. J.; Buckwalter, J. B.; Valic, Z. // Physiological Research;2010, Vol. 59 Issue 3, p331 

    The purpose of this study was to determine if there is flow-mediated vasodilation of the femoral artery in response to progressive increases in flow within a physiological range observed in the in vivo experiments. Femoral artery blood flow was determined in conscious rabbits (n=5) using...

  • Have we missed that neural vasodilator mechanisms may contribute to exercise hyperemia at onset of voluntary exercise? Matsukawa, Kanji; Ishii, Kei; Liang, Nan; Endo, Kana // Frontiers in Physiology;Feb2013, p1 

    Whether neurally-mediated vasodilatation may contribute to exercise hyperemia has not been completely understood. Bülbring and Burn (1935) found for the first time the existence of sympathetic cholinergic nerve to skeletal muscle contributing to vasodilatation in animals. Blair et al. (1959)...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics