Comparative Clinical Evaluation of Two Salts of Quinidine Using 24- Hour Holter Monitor Recordings
- Pure Class III Antiarrhythmic Drugs: Focus on Dofetilide. Doshi, Shephal K.; Singh, Bramah N. // Journal of Cardiovascular Pharmacology & Therapeutics;Dec2000, Vol. 5 Issue 4, p237
The article focuses on dofetilide, one of the pure class III antiarrhythmic drugs. The drug's main electrophysiologic action came from its property of inhibiting the rapid component of the I&Kr during phase 3 of the cardiac action potential. It has no effects on sodium, calcium or other cardiac...
- Maintaining Sinus Rhythm in Atrial Fibrillation by Drug Therapy: Single Agents or Combinations? Singh, Bramah N.; Phil, D.; Doshi, Shephal // Journal of Cardiovascular Pharmacology & Therapeutics;Sep2000, Vol. 5 Issue 3, p139
The article discusses the comparative effects of various drug agents which include solatol, propafenone, quinidine and amniodarone in the treatment of atrial fibrillation (AF) in patients suffering from cardiac arrhythmia. Clinical studies showed that restoration and maintenance of sinus rhythm...
- The Actions of Ibutilide and Class Ic Drugs on the Slow Sodium Channel: New Insights Regarding Individual Pharmacologic Effects Elucidated Through Combination Therapies. Reiffel, James A.; Blitzer, Mark // Journal of Cardiovascular Pharmacology & Therapeutics;Sep2000, Vol. 5 Issue 3, p177
The article focuses on the results of a clinical study on the effects of Ibutilide, an intravenous drug used in the conversion of recent-onset atrial fibrillation (AF) or flutter (AFL) to sinus rhythm in cardiac arrhythmia. Studies presented in the article did a comparative study on the effects...
- Effects of Cilostazol on Heart Rate and its Variation in Patients With Atrial Fibrillation Associated With Bradycardia. Toyonaga, Shinji; Nakatsu, Takaaki; Murakami, Takashi; Kusachi, Shozo; Mashima, Keiichi; Tominaga, Youkou; Yamane, Shinichi; Uesugi, Tadahisa; Kanai, Hideaki; Tsuji, Takao // Journal of Cardiovascular Pharmacology & Therapeutics;Sep2000, Vol. 5 Issue 3, p183
The article presents a study on the effects of cilostazol, a quinolinone derivative, on heart disease patients with atrial fibrillation and who have had bradycardia episodes. The study was conducted with the oral administration of the drug in a period of two months, with baseline Holter...
- CE Questions. // Drug Formulary Review;May2008 Supplement, Vol. 24, Special section p4
A quiz concerning on the clinical efficacy, safety, and effectiveness of the therapeutic agent Rivastigmine is presented.
- DC shock: spontaneous reversion to sinus rhythm during anaesthesia with propanidid. Vecht, R.J.; Galley, R.; Goodwin, P. // British Medical Journal;10/18/1975, Vol. 4 Issue 5989, p143
Presents cases of spontaneous reversion of arrhythmia to sinus rhythm after injection of propanidid. Medical history of the patients; Ability of the drug to depress the conducting system of the heart; Effect of dose or rate of infusion on the antiarrhythmic action of the drug.
- CHEMIMAGE OFFERS BIOEQUIVALANCE TECHNOLOGY FOR DRUG MAKERS. // Biotech Business;Apr2009, Vol. 22 Issue 4, p7
The article reports on the plan of Pittsburgh, Pennsylvania-based ChemImage to help genetic drug makers become the first to achieve bioequivalence for nasal spray suspensions and inhalation products. According to the article, it will do so by providing a faster and more accurate way to determine...
- Failure of Two Commercial Indexes and Spectral Parameters to Reflect the Pharmacodynamic Effect of Desflurane on EEG. Sascha Kreuer; JÃ¶rgen Bruhn; Richard Ellerkmann; Stephan Ziegeler; Darius Kubulus; Wolfram Wilhelm // Journal of Clinical Monitoring & Computing;Apr2008, Vol. 22 Issue 2, p149
Abstract ObjectiveÃ‚Â Ã‚Â We compared two PK/PD models, one with and one without a plateau effect. Bispectral (BIS, Aspect Medical Systems, Natick, MA, version XP) and NarcotrendÃ¢Â„Â¢ (NCT, MonitorTechnik, Bad Bramstedt, Germany, Version 4.0) indices were used as an...
- A Randomized, Double-Blind, Double-Dummy, Multicenter Trial of Voriconazole and Fluconazole in the Treatment of Esophageal Candidiasis in Immunocompromised Patients. Ally, R.; Schurmann, D.; Kreisel, W.; Carosi, G.; Aguirrebengoa, K.; Dupont, B.; Hodges, M.; Troke, P.; Romero, A.J. // Clinical Infectious Diseases;11/1/2001, Vol. 33 Issue 9, p1447
Discusses a study which compared the efficacy, safety and tolerability of voriconazole and fluconazole in immunocompromise patients with mycology- and biopsy-proven esophageal candidiasis. Background of the patients; Findings of efficacy analysis; Safety of the medications.