A Randomized, Double-Blind, Parallel Group Comparison of Disopyramide Phosphate and Quinidine in Patients with Cardiac Arrhythmias

Arif, Mohammed; Laidlaw, James C.; Oshrain, Carl; Willis III, Park W.; Nissen, Catherine H.; McDermott, Daniel J.; Smith, W. Scott; Karim, Aziz; Wilson, Richard R.
June 1983
Angiology;Jun1983, Vol. 34 Issue 6, p393
Academic Journal
This report summarizes the results of a randomized, double-blind, parallel group, multicenter study which compared the antiarrhythmic activity and safety of oral disopyramide phosphate and oral quinidine sulfate. A total of 124 outpatients, whose pretreatment rates of ventricular and/or supraventricular arrhythmias were documented by ambulatory ECG recordings, were randomly assigned to receive either oral disopyramide or oral quinidine for the eight-week course of the study. Every two weeks, ten-hour ambulatory ECG recordings were obtained from each patient and blood was drawn to determine serum concentrations of assigned drug.


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