TITLE

VASCULAR PERMEABILITY IN EXPERIMENTAL BRAIN TUMORS

AUTHOR(S)
Wright, R. Lewis
PUB. DATE
February 1967
SOURCE
Angiology;Feb1967, Vol. 18 Issue 2, p69
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Permeability of the vasculature of methylcholanthrene-induced brain tumors has been studied by tracer injection of fine carbon-black of a nearly standard particle size of 200 Ã…. After the first week of growth vessels of these tumors have shown increasingly abnormal permeability for particles of this size. Such defects have appeared first in the thin-walled veins and venous sinusoids and later have involved capillaries throughout each tumor. Arterial brandies have been spared.
ACCESSION #
16437530

 

Related Articles

  • Characterisation of tumour vasculature in mouse brain by USPIO contrast-enhanced MRI. Gambarota, G.; Leenders, W.; Maass, C.; Wesseling, P.; van der Kogel, B.; van Tellingen, O.; Heerschap, A. // British Journal of Cancer;6/3/2008, Vol. 98 Issue 11, p1784 

    To enhance the success rate of antiangiogenic therapies in the clinic, it is crucial to identify parameters for tumour angiogenesis that can predict response to these therapies. In brain tumours, one such parameter is vascular leakage, which is a response to tumour-derived vascular endothelial...

  • VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts. Nawroth, Roman; Poell, Gregor; Ranft, Alexander; Kloep, Stephan; Samulowitz, Ulrike; Fachinger, Gregor; Golding, Matthew; Shima, David T.; Deutsch, Urban; Vestweber, Dietmar // EMBO Journal;9/15/2002, Vol. 21 Issue 18, p4885 

    VE-cadherin is the essential adhesion molecule in endothelial adherens junctions, and the regulation of protein tyrosine phosphorylation is thought to be important for the control of adherens junction integrity. We show here that VE-PTP (vascular endothelial protein tyrosine phosphatase), an...

  • Epigalloccatechin-3-gallate Inhibits Ocular Neovascularization and Vascular Permeability in Human Retinal Pigment Epithelial and Human Retinal Microvascular Endothelial Cells via Suppression of MMP-9 and VEGF Activation. Hak Sung Lee; Jae-Hyun Jun; Eun-Ha Jung; Bon Am Koo; Yeong Shik Kim // Molecules;Aug2014, Vol. 19 Issue 8, p12150 

    Epigalloccatechin-3-gallate (EGCG) is the main polyphenol component of green tea (leaves of Camellia sinensis). EGCG is known for its antioxidant, anti-inflammatory, antiviral, and anti-carcinogenic properties. Here, we identify EGCG as a new inhibitor of ocular angiogenesis and its vascular...

  • Tumor Microenvironment in the Brain. Lorger, Mihaela // Cancers;Mar2012, Vol. 4 Issue 1, p218 

    In addition to malignant cancer cells, tumors contain a variety of different stromal cells that constitute the tumor microenvironment. Some of these cell types provide crucial support for tumor growth, while others have been suggested to actually inhibit tumor progression. The composition of...

  • Simultaneous perfusion and permeability measurements using combined spin- and gradient-echo MRI. Schmiedeskamp, Heiko; Andre, Jalal B; Straka, Matus; Christen, Thomas; Nagpal, Seema; Recht, Lawrence; Thomas, Reena P; Zaharchuk, Greg; Bammer, Roland // Journal of Cerebral Blood Flow & Metabolism;May2013, Vol. 33 Issue 5, p732 

    The purpose of this study was to estimate magnetic resonance imaging-based brain perfusion parameters from combined multiecho spin-echo and gradient-echo acquisitions, to correct them for T1-, T2-, and -related contrast agent (CA) extravasation effects, and to simultaneously determine vascular...

  • Vascular permeability and drug delivery in cancers. Azzi, Sandy; Hebda, Jagoda K.; Gavard, Julie // Frontiers in Oncology;Aug2013, Vol. 3, p1 

    The endothelial barrier strictly maintains vascular and tissue homeostasis, and therefore modulates many physiological processes such as angiogenesis, immune responses, and dynamic exchanges throughout organs. Consequently, alteration of this finely tuned function may have devastating...

  • Angiopoietin-1 alters microvascular permeability coefficients in vivo via modification of endothelial glycocalyx. Andrew H.J. Salmon; Christopher R. Neal; Leslie M. Sage; Catherine A. Glass; Steven J. Harper; David O. Bates // Cardiovascular Research;Jul2009, Vol. 83 Issue 1, p24 

    : Aims In this study, we wished to determine whether angiopoietin-1 (Ang1) modified the permeability coefficients of non-inflamed, intact continuous, and fenestrated microvessels in vivo and to elucidate the underlying cellular mechanisms. : Methods and results Permeability coefficients were...

  • EIAV vector-mediated delivery of endostatin or angiostatin inhibits angiogenesis and vascular hyperpermeability in experimental CNV. Balaggan, K. S.; Binley, K.; Esapa, M.; MacLaren, R. E.; Iqball, S.; Duran, Y.; Pearson, R. A.; Kan, O.; Barker, S. E.; Smith, A. J.; Bainbridge, J. W. B.; Naylor, S.; Ali, R. R. // Gene Therapy;Aug2006, Vol. 13 Issue 15, p1153 

    We evaluated the efficacy of equine infectious anaemia virus (EIAV)-based lentiviral vectors encoding endostatin (EIAV.endostatin) or angiostatin (EIAV.angiostatin) in inhibiting angiogenesis and vascular hyperpermeability in the laser-induced model of choroidal neovascularisation (CNV). Equine...

  • Visualizing vascular permeability and lymphatic drainage using labeled serum albumin. Vandoorne, Katrien; Addadi, Yoseph; Neeman, Michal // Angiogenesis;Jun2010, Vol. 13 Issue 2, p75 

    During the early stages of angiogenesis, following stimulation of endothelial cells by vascular endothelial growth factor (VEGF), the vascular wall is breached, allowing high molecular weight proteins to leak from the vessels to the interstitial space. This hallmark of angiogenesis results in...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics