Perchuk, Eli; Weinreb, Manfred; Aksu, Ahmet
March 1961
Angiology;Mar1961, Vol. 12 Issue 3, p102
Academic Journal
1. Nocturnal leg cramps are painful complaints encountered fairly often in clinical practice. They occur more frequently in older patients and, while usually not serious, may be severe enough to interfere with the patient's rest. 2. Twenty women and seven men with nocturnal leg cramps were included in the present study. The majority were in the age group of 40 to 80 years. The underlying cause of the cramps included thrombophlebitis and other vascular disorders, pregnancy, profound diuresis after the administration of Mercuhydrin, and a miscellaneous category. Seven patients had cramps of unknown origin. 3. Of the 24 patients who received the active drug, the therapeutic benefits reported by 19 were described as excellent, and 5 were satisfactory. There were no failures in this group. The 3 patients who received placebos and the 3 patients who were alternated between placebos and active drug, had no diminution in the frequency or severity of night cramps while on placebos. Those patients who improved while taking the active drug had a return of symptoms when the drug was discontinued. 4. The benefits of therapy with methocarbamol are comparable to those of quinidine with the added advantage that methocarbamol is nontoxic in the dosages used and has no deleterious effect on normal muscle tone.


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