TITLE

EFFECTS OF HEPARIN ON THE UPTAKE OF LIPIDS BY ISOLATED HUMAN AND ANIMAL ARTERIAL ENDOTHELIAL TYPE CELLS

AUTHOR(S)
Lazzarini-Robertson Jr., Abel
PUB. DATE
October 1961
SOURCE
Angiology;Oct1961, Vol. 12 Issue 10, p525
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Heparin has a strong inhibitory action upon the uptake of labeled serum bound lipids by human and animal endothelial type cells harvested from short term organ cultures of large arteries which fulfill in vitro the functional criteria of endothelium in general. Evidence is presented to the effect that this is due to the physicochemical characteristics of the heparin molecule, particularly its very strong negative charge acting directly at cell membrane level. Several anions and cations under identical conditions produced similar or opposite results depending exclusively on their charges. Since all macromolecules must be bound to the cell surface before intracellular incorporation, the importance of biologic surface active agents in cellular transport mechanisms is emphasized.
ACCESSION #
16434685

 

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