TITLE

CANNULATION WITHOUT VISUAL CONTROL OF MINUTE MESENTERIC VEINS FOR CONTINUOUS PORTAL PERFUSION OF RATS INTOXICATED WITH BROMOBENZENE

AUTHOR(S)
Rappaport, A. M.; Martyn, J. W.; Ross, P. L. E.
PUB. DATE
October 1961
SOURCE
Angiology;Oct1961, Vol. 12 Issue 10, p442
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A technique of cunnulation of minute mesenteric vessels for continuous portal perfusion of the rat in described. The plastic cannula is introduced into the vessel without visual control. The continuous portal perfusion with a glucose, calcium, vitamins C and P solution of rats intoxicated with bromobenzene does not increase their survival rate as compared with a control series infused with glucose-saline. The histologic changes in the liver are less severe in the rats perfused with the vitamin mixture. The in vivo transillumination of the liver during the injection of bromobenzene, and 48 hours afterward, reveals grave circulatory changes in sinusoids and hepatic venules of zone 3 of the liver acini. The sludge in the sinusoids and hepatic venules could be broken up during the early phase by heparin.
ACCESSION #
16434553

 

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