Alimurung, Mariano M.; Paulino-Abundo, Helen; Tan, Angeles L.; Cruz, Pedro M.
September 1963
Angiology;Sep1963, Vol. 14 Issue 9, p480
Academic Journal
Pivalylbenzhydrazine (Tersavid) was administered to 50 patients with angina pectoris, of whom 17 had acute myocardial infarction and the other 33 had coronary insufficiency as proven clinically and electrocardiographically. Based on the observations of chest pain, the results obtained were considered excellent in 33, good in 10, fair in 6, and poor in 1. Thus, remarkable improvement was noted in 43 of the 50 patients studied. No significant side effects were observed on either clinical or laboratory examinations. The electrocardiograms remained essentially unchanged. These, being limited to clinical observations, cannot shed added light on the possible mode of action of amine oxidase inhibitors in the relief of angina pectoris. Indeed, there is suggestion that the underlying pathologic process is not altered at all by these drugs. Therefore, although it appears that amine oxidase inhibitors can bring about significant relief to angina pectoris, patients so treated must still be cautioned against other possible sources of harm to their underlying disorder. Further studies on these drugs are definitely indicated to establish their definite place in the therapy of angina pectoris and to define their precise mode of action.


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