Haan, D.
September 1963
Angiology;Sep1963, Vol. 14 Issue 9, p449
Academic Journal
1. On the basis of experimental and clinica studies with testosterone the extent to which anabolic hormones are able to influence metabolism and contractility of the heart, muscle is discussed; 4-hydroxy-17-alpha-methyl-testosterone (Oranabol) was used for trials in 97 patients suffering from various heart diseases. 2. Comparative investigations showed: (1) in one-quarter of the eases normalization of the tension time and expulsion time, pathological atrial sounds, and EKG alterations regressed; (2) hypoproteinemia was compensated in 8 of 11 patients, while serum electrolyte rallies did not change considerably; (3) blood pressure and pulse frequency were not influenced; (4) nearly always improvement of the general condition was seen; in 9 of 23 patients stenocardia regressed with regard to frequency and intensity; stronger increases in weight occurred only in pathological underweight conditions; (5) in 6 of 23 patients treated, symptoms of insufficiency regressed after treatment with 4-hydroxy-17alpha-methyl-testosterone. 3. According to the findings of the investigation it can be assumed that anabolic hormones are able to influence favorably the disturbed metabolism of the myocardium, and that the performance of contraction of the heart muscle can be improved to a certain extent; a useful substitution therapy of diseases of the heart muscle thus becomes possible.


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