TITLE

CURRENT STATUS OF NITROGLYCERIN OINTMENT IN ANGINA PECTORIS: A NEW LOOK AT AN OLD DRUG

AUTHOR(S)
Abrams, Jonathan
PUB. DATE
March 1977
SOURCE
Angiology;Mar1977, Vol. 28 Issue 3, p217
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
These investigations, summarized in Table 1, all unequivocally demonstrate that nitroglycerin ointment is pharmacologically active and provides a true sustained duration of action. In patients with angina, exercise tolerance, chest pain, peak work load, and ST depression are impressively improved. In patients with depressed left ventricular function and elevated cardiac filling pressures, nitroglycerin ointment results in prolonged reductions in PAW and mean arterial pressures. Cardiac output may actually increase in the sicker hearts, presumably as a response to impedance or afterload reduction. Left ventricular dimensions and volumes are significantly diminished for at least 3 hours after nitroglycerin ointment administration. These studies are all consistent with the concept that nitroglycerin acts predominantly by decreasing myocardial oxygen demands through reductions in preload and afterload,'" two critical determinants of myocardial wall tension.
ACCESSION #
16434305

 

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