Bilateral Asymmetry in Chinese Families With Cleft Lip With or Without Cleft Palate

March 2005
Cleft Palate-Craniofacial Journal;Mar2005, Vol. 42 Issue 2, p192
Academic Journal
Objective: To determine if Chinese individuals with nonsyndromic cleft lip with or without cleft palate (CL/P) display more bilateral asymmetry than do their unaffected relatives. Design/Subjects: A case-control study of 313 individuals with CUP from Shanghai, China, with 201 unaffected relatives as controls. Methods: Size-adjusted asymmetry scores were defined by data on middle-finger length, palm length, palpebral fissure width, and ear length. Case-control comparisons used a multivariate repeated measures analysis of variance, paired t tests, and the Wilcoxon signed rank test. Results: The ear-length measure showed a significant increase in fluctuating asymmetry (FA) in individuals with CUP compared with their unaffected relatives, which was most pronounced in the female cleft lip and palate subgroup (p = .04). No other measures showed any increase in FA. Conclusion: Evidence was found for increased FA, as measured by overall ear length, in Chinese individuals with nonsyndromic CL/P, compared with their unaffected family members. The use of bilateral measurements other than dermatoglyphics may prove to be a valuable means of assessing overall developmental stability in individuals with developmental malformations and in their families.


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