TITLE

Effect of Alendronate on Vertebral Fracture Risk in Women With Bone Mineral Density T Scores of-1.6 to -23 at the Femoral Neck: The Fracture Intervention Trial

AUTHOR(S)
Quandt, Sara A.; Thompson, Desmond E.; Schneider, Diane L.; Nevitt, Michael C.; Black, Dennis M.
PUB. DATE
March 2005
SOURCE
Mayo Clinic Proceedings;Mar2005, Vol. 80 Issue 3, p343
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVES: To determine the efficacy of alendronate treatment on risk of vertebral fracture in a subgroup of women from the Fracture Intervention Trial who had bone mineral density T scores between -1.6 and -2.5 at the femoral neck and to describe how soon after initiation of therapy alendronate becomes effective and whether It is consistent in women with and without existing radiographic vertebral fracture. PATIENTS AND METHODS: From May 1992 to March 1997, postmenopausal women aged 55 to 80 years were randomized to receive alendronate at 5 mg/d for 2 years and 10 mg/d thereafter or placebo for up to 4.5 years (mean, 3.8 years) in a controlled, double-blind, multicenter study. RESULTS: A total of 3737 postmenopausal women were included in the study, 1878 in the alendronate group and 1859 in the placebo group. Risk of vertebral fracture was significantly reduced by alendronate compared with placebo for clinical (relative risk [RR], 0.40; 95% confidence interval [CI], 0.19–0.76; P=.005) and radiographic (RR, 0.57; 95% CI, 0.41–0.81; P=.002) fracture. The reductions In vertebral fracture risk were consistent in women with and without an existing radiographic vertebral fracture for clinical (RR, 0.34; 95% CI, 0.12–0.84; and RR, 0.46; 95% CI, 0.16–1.17; respectively) and radiographic (RR, 0.53; 95% CI, 0.34–0.82; and RR, 0.64; 95% CI, 0.3S-1.10; respectively) fractures. In both groups, the effect of alendronate on clinical vertebral fracture was noted soon after therapy was Initiated. The absolute risk of vertebral fracture was low in women without a baseline radiographic fracture. CONCLUSIONS: In women with low bone mass who do not meet the bone mineral density criterion for osteoporosis, alendronate is effective In reducing the risk of vertebral fractures. The absolute benefit of this therapy in women with a T score between -1.6 and -2.5 Is greater In women with an existing vertebral fracture and/or with other risk factors. The effect of alendronate occurs early.
ACCESSION #
16433832

 

Related Articles

  • FRAGILITY FRACTURE: WHAT IS IT AND WHAT CAN WE DO? M. M., Darhaysyam Al Jefri; F., Emil; Y., Ahmad Sallehudin // Malaysian Journal of Medical Sciences;Jan2008 Supplement, p247 

    Introduction : Osteoporosis is defined as a systemic skeletal disease characterized by low bone mass and micro-architectural deterioration of bone tissue, which consequent increase in bone fragility and susceptibility to fracture. Osteoporosis related fracture or fragility fracture has been...

  • Does a history of non-vertebral fracture identify women without osteoporosis for treatment? Ryder, Kathryn M; Cummings, Steven R.; Palermo, Lisa; Satterfield, Suzanne; Bauer, Douglas C; Feldstein, Adrianne C.; Schousboe, John T.; Schwartz, Ann V.; Ensrud, Kristine; Fracture Intervention Trial Research Group // JGIM: Journal of General Internal Medicine;Aug2008, Vol. 23 Issue 8, p1177 

    Background: Postmenopausal women with a prior fracture have an increased risk for future fracture. Whether a history of non-vertebral fracture defines a group of women with low bone mass but without osteoporosis for whom alendronate would prevent new non-vertebral fracture is not...

  • Potential cost-effective use of spine radiographs to detect vertebral deformity and select osteopenic post-menopausal women for amino-bisphosphonate therapy. Schousboe, John; Ensrud, Kristine; Nyman, John; Kane, Robert; Melton, L. // Osteoporosis International;Dec2005, Vol. 16 Issue 12, p1883 

    Prevalent vertebral deformities are predictive of future clinical fractures independent of bone density. We used a Markov model with eight health states to estimate from the societal perspective the cost-effectiveness of using spine radiographs to identify postmenopausal women age 60 or older...

  • Hip fractures up to date. Ring, P.A. // British Medical Journal;12/11/1976, Vol. 2 Issue 6049, p1429 

    Examines the fractures of the femoral neck in the elderly in Europe. Occurrence of the basal neck fractures at the junction of the neck and the trochanteric region; Association of the injury with senile osteoporosis; Risks associated with prolonged immobilization in the elderly.

  • Focus on falls needed to head off rise in fractures.  // New Zealand Doctor;3/23/2011, p8 

    The article discusses a study in the January 2011 issue of "Osteoporosis International" from the Dunedin School of Medicine where it was found that the increased survival of frail people is affecting the incidence of femoral neck fracture and emphasizes the need for health professionals to...

  • Relevance of osteoporosis in women with fracture of the femoral neck. Aitken, J.M. // British Medical Journal (Clinical Research Edition);2/25/1984, Vol. 288 Issue 6417, p597 

    Examines the relevance of osteoporosis in women with fracture of the femoral neck in the United States. Irrelevance of the history of fractures to the severity of osteoporosis; Prevalence of trochanteric fractures in severely osteoporotic women; Availability of highly reproducible methods for...

  • Age- and gender-dependent changes in three-dimensional microstructure of cortical and trabecular bone at the human femoral neck. Chen, H.; Zhou, X.; Shoumura, S.; Emura, S.; Bunai, Y. // Osteoporosis International;Apr2010, Vol. 21 Issue 4, p627 

    We investigated age- and gender-related variation of both cortical and trabecular microstructure in human femoral neck. We found that age-related change of cortical porosity is more noticeable than that of trabecular parameter. Our data may help to gain more insight into the potential mechanism...

  • Osteoporose. Buck, Gabriela // Praxis (16618157);7/6/2011, Vol. 100 Issue 14, p821 

    No abstract available.

  • CORRESPONDENCE.  // British Medical Journal (Clinical Research Edition);4/7/1984, Vol. 288 Issue 6423, p1083 

    Presents several letters on medicine. Relevance of osteoporosis in women with femoral neck fracture; Decrease in the incidence of cerebral abscesses; Features of chest radiographs as indicators of alcoholism in patients with liver disease.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics