Strong Association between Gallstones and Cardiovascular Disease

Méndez-Sánchez, Nahum; Bahena-Aponte, Jesus; Chávez-Tapia, Norberto C.; Motola-Kuba, Daniel; Sánchez-Lara, Karla; Ponciano-Radriguez, Guadalupe; Ramos, Martha H.; Uribe, Misael
April 2005
American Journal of Gastroenterology;Apr2005, Vol. 100 Issue 4, p827
Academic Journal
BACKGROUND AND AIM: Obesity is closely associated with the increased morbidity and mortality of many common diseases in the Western world, including coronary heart disease (CHD) and gallstone diseases (GD). We have investigated the association between GD and CHD in a cross-sectional study.METHODS AND RESULTS: Subjects who had gallstones visible by ultrasound were considered as cases and subjects negative for gallstones were classified as controls. Positive CHD was defined when the stress test was positive. Body mass index (BMI), waist circumference, blood pressure, serum lipid concentrations, and insulin resistance were measured. The association was estimated by odds ratios using logistic regression models adjusted for confounders. Four hundred and seventy-three subjects (292 males and 181 females) were included, comprising 354 controls and 119 cases. Subjects with GD had higher prevalence of CHD (15.96%) than controls (4.52%) (p<0.0001). In univariate unconditional logistic regression analysis CHD, BMI≥ 30 kg/m2, waist circumference, high blood pressure, and HOMA-IR>2.5 were the most important risk factors for GD. In multivariate analysis (adjusted for age and gender, and BMI) the risk for GD in subjects with CHD was higher (OR 2.84, 95% CI: 1.33–6.07,p<0.007).CONCLUSIONS: Subjects with CHD have an increased risk to have GD, both diseases are strongly associated and the main characteristics of these subjects are those frequently involved as part of the metabolic syndrome.(Am J Gastroenterol 2005;100:1–4)


Related Articles

  • Prognostic factors of acute cholangitis in cases managed using the Tokyo Guidelines. Tsuyuguchi, Toshio; Sugiyama, Harutoshi; Sakai, Yuji; Nishikawa, Takao; Yokosuka, Osamu; Mayumi, Toshihiko; Kiriyama, Seiki; Yokoe, Masamichi; Takada, Tadahiro // Journal of Hepato -- Biliary -- Pancreatic Sciences;Sep2012, Vol. 19 Issue 5, p557 

    Background/purpose: In 2007, the Tokyo Guidelines (TG07) working group established diagnostic criteria for assessment of the severity of acute cholangitis. This study aimed to analyze outcomes and identify predictors of mortality in patients with acute cholangitis managed according to the TG07....

  • Gallstones can signal CAD.  // Cortlandt Forum;6/25/2005, Vol. 18 Issue 6, p19 

    Reports on the finding that 16% of patients in Mexico City with ultrasound-visible gallstones had coronary artery disease (CAD), which was confirmed with stress testing. Rate of CAD among the controls without gallstones; Risk factors for gallstones.

  • Effect of medical or surgical admission on outcome of patients with gallstone pancreatitis and common bile duct stones. LaFemina, Jennifer; Sokal, Suzanne M.; Chang, Yuchiao; McGrath, Deborah; Berger, David L. // Journal of Gastrointestinal Surgery;Sep2008, Vol. 12 Issue 9, p1554 

    Introduction: Management of uncomplicated common bile duct stone (CBDS) and gallstone pancreatitis (GP) presumably varies based on whether a patient is admitted to medicine or surgery. This study evaluates the impact of admitting team on outcome and cost.Methods: Three...

  • Treatment options for common bile duct stones. Ferguson, H.R.; Robinson, T.J. // Postgraduate Medical Journal;Mar2003, Vol. 79 Issue 929, p178 

    Presents several self-assessment questions regarding treatment options for an 83-year-old woman with common bile duct stones. Symptoms; Diagnosis; Implications on medical research.

  • SELF ASSESSMENT ANSWERS: Treatment options for common bile duct stones.  // Postgraduate Medical Journal;Mar2003, Vol. 79 Issue 929, p181 

    Presents the answers to several self-assessment questions regarding treatment options for an 83-year-old woman with common bile duct stones. Symptoms; Diagnosis; Implications on medical research.

  • chololith.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p441 

    An encyclopedia entry for "chololith" which refers to gallstone is presented.

  • chololithiasis.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p441 

    An encyclopedia entry for "chololithiasis" is presented.

  • Gallbladder disease. Bateson, Malcolm C. // BMJ: British Medical Journal (International Edition);06/26/99, Vol. 318 Issue 7200, p1745 

    Focuses on the pathophysiology and treatment of gall stones. Function of the gall bladder; How gall stones may be detected; True symptoms of gall stones.

  • A questionnaire for the assessment of biliary symptoms. Romero, Yvonne; Thistle, Johnson L.; Longstreth, George F.; Harmsen, W. Scott; Schleck, Cathy D.; Zinsmeister, Alan R.; Pardi, Darrell S.; Zein, Claudia O.; Van Dyke, Carol T.; Arora, Amindra S.; Locke III, G. Richard // American Journal of Gastroenterology;May2003, Vol. 98 Issue 5, p1042 

    : ObjectivesGallstone disease is common and causes high health care costs, but a measure of symptomatic biliary disease for outcome studies is lacking. We aimed to develop a reproducible, valid, discriminative, disease-specific measure of biliary symptoms.: MethodsWe created the self-report...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics