TITLE

Blood Flow Properties and Walking Performance in Chronic Arterial Occlusive Disease

AUTHOR(S)
Angelkort, B.; Spürk, P.; Habbaba, A.; Mähder, M.
PUB. DATE
May 1985
SOURCE
Angiology;May1985, Vol. 36 Issue 5, p285
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Recent investigations suggest an interdependence between blood fluidity and walking performance in patients with peripheral arterial occlusive disease (PAOD). Therefore, various blood fluidity variables (erytbrocyte aggregation, erytbrocyte flexibility, plasma viscosity, plasma proteins) were studied in groups of healthy subjects and claudicants with severe PAOD (exhausted perfusion reserve) receiving intravenous treatment with Trental (600 mg Pentoxifylline b.i.d., 21 days). Erytbrocyte flexibility (expressed by filterability through micropore filters), red cell aggregation and plasma viscosity deteriorate with progression of disease especially in Stage lib and III Fontaine classification, with walking distance below 150 m. Trental treatment resulted in patients with advanced POAD stages in improvement of red cell filterability, red cell aggregation, decrease of plasma viscosity, increase in absolute walking distance and relief from rest pain, suggesting that such patients are accessible to conservative treatment with hemorheologically active agents.
ACCESSION #
16433253

 

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