Simms, Henry S.; Harmison, Charles R.
November 1966
Angiology;Nov1966, Vol. 17 Issue 11, p872
Academic Journal
The fat-depositing free lipfanogens and the opposing antilipfanogen in blood serum have been studied by quantitative tissue culture methods. Although the free (uncombined) lipfanogens of the blood serum were previously found largely in the residual solution after removal of all lipoproteins, the present studies show a positive correlation between the free lipfanogens and the Sf20�400 lipoprotein fraction. This indicates that some of the lipfanogens may be associated with this fraction. The free lipfanogens are also correlated with Gofman's atherogenic index. The antilipfanogen (which is also found largely in the lipoprotein-free residue) is partly correlated with the high density HDL2 fraction. Diabetics in acidosis and ketosis were found to have a high level of free lipfanogens (25 per cent above the controls) and a low antilipfanogen level (40 per cent below the controls), a condition favorable to fat deposition. After several hours of insulin administration the average level of free lipfanogens was found to have fallen markedly while the free antilipfanogen level was increased. The ratio of lipfanogens to antilipfanogen decreased 71 per cent during the insulin treatment. Species that are prone to atherosclerosis (including man) have a low antilipfanogen level and a high level of lipfanogens. On the other hand, species that are resistant to atherosclerosis have high levels of antiliptanogen. It is suggested that the prevalence of atherosclerosis in man may (in part at least) be the result of an antilipfanogen deficiency.


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