Sussman, Bernard J.; Fitch, Thomas S. P.
May 1961
Angiology;May1961, Vol. 12 Issue 5, p169
Academic Journal
Eleven patients with angiographically demonstrated cerebral or carotid occlusions were treated with fibrinolysin. Evidence of vascular clearing was obtained in 5 patients. Partial results were noted in 2 cases. The authors favor intracarotid administration of the enzyme. Clinical evaluation without angiographic study is considered misleading and unreliable. No hemorrhagic complications could be attributed to the use of this new agent. The specific usefulness of the enzyme in embolic cerebral occlusions is suggests.


Related Articles

  • THROMBOLYSIS WITH FIBRINOLYSIN IN CEREBRAL ARTERIAL OCCLUSION; THE ROLE OF ANGIOGRAPHY. Sussman, Bernard J.; Fitch, Thomas S. P. // Angiology;Aug1959 Part 2, Vol. 10 Issue 4, p268 

    Nine patients with demonstrable cerebral or carotid occlusions have been treated with fibrinolysin. The results of treatment have been interpreted on the basis of follow-up angiograms or postmortem studies. Favorable results marked by vascular clearing have been obtained in 4 cases. Three of...

  • S100B as a surrogate marker for successful clot lysis in hyperacute middle cerebral artery occlusion. Foerch, C.; de Rochemont, R. du Mesnil; Singer, O.; Neumann-Haefelin, T.; Buchkremer, M.; Zanella, F. E.; Steinmetz, H.; Sitzer, M.; du Mesnil de Rochemont, R // Journal of Neurology, Neurosurgery & Psychiatry;Mar2003, Vol. 74 Issue 3, p322 

    Objectives: The astroglial protein S100B is a marker of cerebral tissue damage. This study investigated whether the serum kinetic of S100B may serve as a surrogate marker of successful clot lysis and early recanalisation (<6 hours) in hyperacute proximal middle cerebral artery...

  • Microglial low-density lipoprotein receptor-related protein 1 mediates the effect of tissue-type plasminogen activator on matrix metalloproteinase-9 activity in the ischemic brain. Chen Zhang; Jie An; Haile, Woldeab B.; Echeverry, Ramiro; Strickland, Dudley K.; Yepes, Manuel // Journal of Cerebral Blood Flow & Metabolism;Dec2009, Vol. 29 Issue 12, p1946 

    Studies in animal models of cerebral ischemia indicate that besides its thrombolytic effect, treatment with tissue-type plasminogen activator (tPA) also induces an increase in matrix metalloproteinase-9 (MMP-9) activity in the ischemic tissue associated with the development of cerebral edema....

  • Therapeutische Ultraschallbehandlung des akuten Hirnarterienverschlusses. M. Nedelmann; T. Gerriets; M. Kaps // Der Nervenarzt;Dec2008, Vol. 79 Issue 12, p1399 

    Zusammenfassung  Die durch Ultraschall beschleunigte beziehungsweise induzierte Gefäßrekanalisation, die so genannte Sonothrombolyse, stellt ein neuartiges Therapiekonzept in der Schlaganfallbehandlung dar. Verschiedene experimentelle und klinische Studien belegen die synergistischen...

  • Direct aspiration first pass technique for a middle cerebral artery occlusion with a hidden aneurysm. Asai, Katsunori; Nakamura, Hajime; Sakaguchi, Manabu; Kawano, Tomohiro; Ozaki, Tomohiko; Ima, Hiroyuki; Kidani, Tomoki; Kadono, Yoshinori; Murakami, Tomoaki; Yoshimine, Toshiki // Interventional Neuroradiology;Dec2015, Vol. 21 Issue 6, p700 

    Hidden aneurysms within occluded vessels present a challenge for interventionists because vessel perforation can lead to life-threatening complications. We present a case of middle cerebral artery ischemic stroke, refractory to thrombolysis. A direct aspiration first pass technique (ADAPT) was...

  • Management of acute basilar artery occlusion: Should any treatment strategy prevail? Dornak, Tomas; Herzig, Roman; Sanak, Daniel; Skoloudik, David // Biomedical Papers of the Medical Faculty of Palacky University i;Dec2014, Vol. 158 Issue 4, p528 

    Background. Acute basilar artery occlusion (BAO) is relatively infrequent form of acute ischemic stroke associated with severe and persisting neurological deficit and high mortality rate (to 86%). Early recanalization is essential for good clinical outcome but the most effective treatment...

  • From Bad to Worse: Intravenous Thrombolysis in Tandem Occlusion. Tütüncü, Serdar; Ziegler, Annerose; Fiebach, Jochen; Audebert, Heinrich; Nolte, Christian // Turkish Journal of Neurology / Turk Noroloji Dergisi;Dec2012, Vol. 18 Issue 4, p173 

    We report a stroke patient with tandem occlusion of both the distal middle cerebral artery (MCA) and the ipsilateral internal carotid artery (ICA) who deteriorated clinically after intravenous thrombolysis in spite of recanalization of the ICA because of new proximal MCA (main-stem) occlusion....

  • Tirofiban combined with urokinase selective intra-arterial thrombolysis for the treatment of middle cerebral artery occlusion. LEI FENG; JUN LIU; YUNZHEN LIU; JIAN CHEN; CHUNHAI SU; CHUANFENG LV; YUZHEN WEI // Experimental & Therapeutic Medicine;Mar2016, Vol. 11 Issue 3, p1011 

    The aims of the present study were to establish a model of embolic stroke in rabbits and to evaluate the efficacy and safety of intra-arterially administered tirofiban combined with urokinase thrombolysis. The middle cerebral artery occlusion model (MCAO) of embolic stroke was established in New...

  • EXPERIENCE WITH FIBRINOLYTIC THERAPY OF VASCULAR OCCLUSIVE DISEASE. Warner, W. L. // Vascular Surgery;Nov/Dec1977, Vol. 11 Issue 6, p364 

    1. There may well be a place for streptokinase therapy in selected patients with chronic arterial occlusion, but the emphasis should be on developing information on selection criteria. 2. Efficacy and safety have been established for the use of streptokinase in occluded AV cannulae, but this may...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics