TITLE

THE EFFECT OF FIBRINOLYSIN ON THE INCIDENCE OF THROMBOSIS IN SMALL-ARTERY SUTURING

AUTHOR(S)
Engler, Harold; Headley, William; Clough, L. R.; Moretz, William H.
PUB. DATE
May 1961
SOURCE
Angiology;May1961, Vol. 12 Issue 5, p152
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This study illustrates the high incidence of thrombotic occlusion of anstomoses in small arteries. The incidence of thrombosis occurring at end-to-end anastosmoses in small transected arteries in a group of dogs receiving fibrinolysin intravenously is compared with that of a group of similar (logs not receiving fibrinolysin. The effect of fibrinolysin on thrombosis in longitudinal arteriotomies was studied similarly. Under the conditions of these experiments no benefit from the fibrinolysin could be demonstrated in the prevention of thrombosis in the transected group. It may be that the factors favoring the formation of a thrombus at the circumferential suture line of these vessels are so strong that thrombosis cannot be prevented by the action of fibrinolysin alone. In longitudinal incisions the incidence of thrombosis was lower than in transections whether fibrinolysin was administered or not. With the use of fibrinolysin this incidence of thrombosis was only 11 per cent as compared with 25 per cent when no fibrinolysin was used. This suggests that, under the conditions of this experiment, fibrinolysin may have offered some degree of protection against thrombosis at longitudinal suture lines.
ACCESSION #
16430604

 

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