Development of hepatocellular carcinoma after sustained response to interferon therapy: how long should sustained responders with risk factors be followed?

Kasahara, Akinori
February 2005
Journal of Gastroenterology;Feb2005, Vol. 40 Issue 2, p220
Academic Journal
The article presents information related to hepatocellular carcinoma and effect of interferon therapy. Hepatocellular carcinoma (HCC) is one of the most common malignancies, especially in Southeast Asia, and a major cause of death for patients with chronic hepatitis C virus (HCV) infection. Interferon was introduced worldwide as a therapy for patients with chronic hepatitis C. Although a significant decrease in the incidence of HCC has been observed in patients with sustained response, HCC is detected in some of them. HCC in sustained responders was demonstrated to often be a larger33,43 and less-differentiated tumor than HCC in nonsustained responders when it was detected, 43 most likely because of the extended interval of screening for HCC after patients attained a sustained response to interferon therapy.


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