TITLE

Effect of Coronary Vasodilating Drug on Myocardial Work

AUTHOR(S)
Winsor, Travis; Winsor, David W.; Krohn, Bernard G.; Bernett, Jorge R.
PUB. DATE
June 1982
SOURCE
Angiology;Jun1982, Vol. 33 Issue 6, p393
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The purpose of this paper is to show, by noninvasive measurements, previously undocumented effects on cardiac work of the nitrate coronary vasodilator Pentaerythritol Tetranitrate (Peritrate®). The chew-and-swallow 40-mg tablets of this drug were given to 10 patients of type 11 AHA classification. The Diastolic Time Tension Index/Systolic Time Tension Index Ratio increased significantly from 1.15 (±0.11 SEM) to 1.46(±0.13), p<0.05. The Double Product decreased significantly from 9813 (±606) to 8336 (±497), p<0.01. The Triple Product also decreased significantly from 3223 (± 235) to 2425 (±206), p<0.01. The percent diastole of the R-R interval increased significantly from 65% (± 2.44) to 70% (± 1.73) p<0.05, while no significant change in heart rate occurred (63.2 bts/min to 62.4 bts/min). Correspondingly, there was a decrease of systolic time interval, from 0.33 second (±0.2) to 0.29 second (±.01) p<0.01. A significant decrease in blood pressure was also noted. Systolic BP dropped from 155 (±8.0) to 134(±7.2), p<0.01. Diastolic BP dropped from 89.2 (±2.8) to 79.2 (±2.2), p<0.01. This study shows that Peritrate produced significantly favorable changes in all the cited indicators of cardiac work.
ACCESSION #
16406415

 

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