TITLE

Effect of the Kallikrein Inhibitor Aprotinin on Myocardial Ischemia and Necrosis in Man

AUTHOR(S)
Cecefia-Seldner, Felipe A.; Villarreal, Jorge
PUB. DATE
July 1980
SOURCE
Angiology;Jul1980, Vol. 31 Issue 7, p488
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The effect of administration of aprotinin, a serine esterase inhibitor capable of inactivating kallikrein, on the extent and severity of acute myocardial ischemic injury and subsequent necrosis, was studied in 25 patients. Another group of 25 patients who did not receive aprotinin served as a control group. We administered 100,000 kallikrein inhibitor units (KIU) of aprotinin as a bolus dose, followed by a continuous infusion (4 ml/min) that contained 10,000 KlU/kg in 240 ml of dextrose/water solution, to all 25 patients admitted to the hospital within 30 to 60 minutes after the onset of acute myocardial ischemia. To measure the effect of aprotinin, three parameters were studied; the sum of S-T segment elevations (2ST), the development of Q waves, and the prediction of infarct size by measuring the disappearance rate of creatine phosphokinase (MB CPK isoenzyme). The average EST in the treated group decreased from 40.5 ± 7.00 mv to 12.95 ± 4.60 mv (P < 0.01); in contrast the control group's ΣST did not change significantly, from 54.25 ± 8.02 to 51.7 ± 6.8. Deeper Q waves evolved in the control group compared to the treated group: AQ (6 hours) = 1.0 ST (15 min) + 1.19 (25 patients, r = 0.78); and in the treated group ΔQ (6 hours) = 0.66 ST (15 min) + 0.91 (25 patients, r = 0.65) (P < 0.025). In the control group the estimated infarct size was 57.4 ± 4 CPK-gram-equivalents (CPK-g-Eq). There was significantly less damage in the treated group: 19 ± 2 CPK-g-Eq (P < 0.01). Thus we conclude that aprotinin diminishes myocardial damage.
ACCESSION #
16405829

 

Related Articles

  • Stage-Specific Inhibition of Xenopus Embryogenesis by Aprotinin, a Serine Protease Inhibitor1. Iijima, Ryoko; Yamaguchi, Shinji; Homma, Ko-ichi; Natori, Shunji // Journal of Biochemistry;1999, Vol. 126 Issue 5, p912 

    We examined the effects of various protease inhibitors on Xenopus laevis embryogenesis. Aprotinin, a serine protease inhibitor, was found to inhibit embryogenesis markedly, but other protease inhibitors had virtually no effect. The inhibitory effect of aprotinin was specific for embryos at the...

  • Inhibition of trypsin by heparin and dalteparin, a low molecular weight heparin. Bosnic, Olivera M.; Gopcevic, Kristina R.; Vrvic, Miroslav M.; Karad�ic, Ivanka M. // Journal of the Serbian Chemical Society;Apr2009, Vol. 74 Issue 4, p379 

    The interaction between trypsin, a prototype S1 serine protease, with heparin and its low molecular weight derivative dalteparin were investigated. Direct inhibition of the proteolytic activity of trypsin by heparin and dalteparin, used in concentrations typical for their clinical application,...

  • Apical thrombus associated with left ventricular apical ballooning. Barrera-Ramirez, C.F.; Jimenez-Mazuecos, J.M.; Alfonso, F. // Heart;Aug2003, Vol. 89 Issue 8, p927 

    Discusses the case of a 64-year-old female patient presenting with apical thrombus associated with left ventricular apical ballooning. Clinical signs and symptoms; Creatine phosphokinase and troponin I values.

  • Cardiac enzyme release following percutaneous coronary intervention. Causer, J.; Wood, M.; Stables, R.H. // Current Medical Literature: Interventional Cardiology Monitor;2003, Vol. 10 Issue 2, p31 

    Examines the cardiac enzyme release following percutaneous coronary intervention in the U.S. Levels of creatine kinase; Diagnosis of myocardial infarction; Measurement of biochemical markers of the disease.

  • Coronary Artery Disease - Myocardial Infarction.  // Current Medical Literature: Interventional Cardiology Monitor;2006, Vol. 13 Issue 3, p81 

    The article assesses several studies related to myocardial infarction. One study concluded that peak creatine kinase level is a sign of 1 year mortality rate and left ventricular function following primary percutaneous coronary intervention (PCI). Another study provided a comparison of the...

  • Vessel masking improves densitometric myocardial perfusion assessment. Tamás Ungi; Zsolt Zimmermann; Erika Balázs; András Lassó; Imre Ungi; Tamás Forster; András Palkó; Attila Nemes // International Journal of Cardiovascular Imaging;Mar2009, Vol. 25 Issue 3, p229 

    Abstract   Introduction The objective of treatment in acute myocardial infarction (AMI) is reperfusion of the myocardium at risk. Our goal was to evaluate the effect of vessel masking on videodensitometric assessment of myocardial reperfusion. Methods Epicardial vessels were masked out...

  • Use of the BD Vacutainer Rapid Serum Tube Reduces False-Positive Results for Selected Beckman Coulter Unicel DxI Immunoassays. Strathmann, Frederick G.; Ka, Michael M.; Rainey, Petrie M.; Baird, Geoffrey S. // American Journal of Clinical Pathology;Aug2011, Vol. 136 Issue 2, p325 

    We investigated the use of serum samples from BD Vacutainer rapid serum tubes (RSTs; BD, Franklin Lakes, NJ) to reduce undetermined interferences contributing to false-positive immunoassay results in heparin plasma samples. Patients being evaluated for suspected myocardial infarction had...

  • Effect of the Inhibition of Mitochondrial Creatine Kinase Activity on the Clinical Diagnosis of Suspected Acute Myocardial Infarction. Maekawa, Masato; Sugiura, Aya; Iwahara, Kunihiro; Sakai, Yasuhiro; Kishi, Kouji // Open Clinical Chemistry Journal;2012, Vol. 5, p1 

    Background: Creatine kinase isoenzyme MB (CK-MB) activity using the immunoinhibition method has been measured in clinical laboratories. However, the presence of mitochondrial CK (MtCK) abnormally increases CK-MB activity when measured using the conventional method, which can lead to misdiagnosis...

  • Prognostic implications of increased cardiac biomarkers and ST segment depression in non-ST elevation acute coronary syndromes: lessons from the acute coronary syndrome Israeli survey (ACSIS) 2002. Ben-Dor, I.; Hasdai, D.; Behar, S.; Zahger, D.; Leor, J.; Hammerman, H.; Sandach, A.; Hod, H.; Gottlieb, S. // Heart;Apr2006, Vol. 92 Issue 4, p547 

    The article examines the complementary prognostic information that cardiac troponin, creatine kinase (CK) and ST segment depression offer in the risk stratification of unselected patients presenting with non-ST elevation acute coronary syndromes in Great Britain. Survey results indicate that in...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics