Small-Vessel Disease: Diabetic Microangiopathy

Williamson, Joseph R.; Kilo, Charles
July 1980
Angiology;Jul1980, Vol. 31 Issue 7, p448
Academic Journal
This article presents information on diabetic microangiopathy. Small-vessel disease has long been associated with diabetic retinopathy and nephropathy; indeed, retinal microaneurysms and thickening of glomerular capillary basement membranes are considered to be characteristic, if not specific, manifestations of diabetic vascular disease in these organs. The possibility that small-vessel disease might contribute to myocardial dysfunction and to atherosclerotic vascular disease, as well as to diabetic neuropathy, has also attracted considerable interest. One of the most intriguing characteristics of late complications of diabetes is that they all affect cells and tissues considered not to require insulin for glucose uptake. Numerous studies in experimental animals and in man indicate that diabetic vascular disease is in some way a consequence of the metabolic disturbances resulting from insulin deficiency.


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