The Role of Vasodilating Agents in the Treatment of Chronic Heart Failure

Gunnar, Rolf M.
August 1980
Angiology;Aug1980, Vol. 31 Issue 8, p526
Academic Journal
The article presents information on the role of vasodilating agents in the treatment of chronic heart failure. The compensatory mechanisms which appear in patients with cardiac failure are not released early enough, and, therefore, become part of the problem rather than part of the solution. As blood flow falls, the renin-angiotensin system is activated and angiotensin causes constriction of the peripheral arteries, thus increasing the work of the heart. The determinants of myocardial oxygen consumption are intramyocardial wall tension, which is made up of systolic pressure and ventricular volume, myocardial contractility, which is really related to sympathetic drive and the heart rate, and the duration of systole, which again relates to heart rate and the systolic ejection period.


Related Articles

  • CPR's smarter sister? Gutfeld, G.; Meyers, M. // Prevention;Jun91, Vol. 43 Issue 6, p15 

    Considers a simple variation of cardiopulmonary resuscitation (CPR) which may double the survival rate of cardiac arrest victims. Uses `counterpulsation' or pressure on the upper abdomen to boost blood flow to the heart; Technique is called `Interposed Abdominal Counterpulsation.'

  • Therapeutic Potential of Vasopressin Receptor Antagonists. Ali, Farhan; Guglin, Maya; Vaitkevicius, Peter; Ghali, Jalal K. // Drugs;2007, Vol. 67 Issue 6, p847 

    Arginine vasopressin (AVP) is a neuropeptide hormone that plays an important role in circulatory and sodium homeostasis, and regulating serum osmolality. Several clinical conditions have been associated with inappropriately elevated levels of AVP including heart failure, cirrhosis of the liver...

  • Antioxidant treatment for heart failure: friend or foe? M. J. Thomson; M. P. Frenneaux; J. C. Kaski // QJM: An International Journal of Medicine;May2009, Vol. 102 Issue 5, p305 

    Increasing studies demonstrate a pivotal role for oxidant stress in the pathophysiology of heart failure (HF). Recent meta-analyses also reveal the potential pitfall of a mono-dimensional antioxidant approach. This review article summarizes the main biological pathways involved in oxidant stress...

  • Levosimendan: a decade of experience in Europe built on years of evidence. Parissis, John; Toller, Wolfgang; Franco, Fatima; Delgado, Juan F.; Danou, Fotini; Llorens-Soriano, Pere; Karpati, Peter C.J.; Nieminen, Markku S.; Mebazaa, Alexandre; Follath, Ferenc // European Journal of Heart Failure. Supplements;Jun2008, Vol. 7 Issue 2, p234 

    Abstract: Recent European Society of Cardiology''s (ESC) guidelines on the diagnosis and treatment of acute heart failure (AHF), suggest that an essential target in the management of these patients is to improve symptoms within hours, which should persist until hospital release, also protecting...

  • congestion.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p508 

    A definition of the term "congestion," which refers to an excessive amount of blood flow to a part or from dilatation of blood vessels, is presented.

  • Mayo Clinic Researchers Discover Gene Mutations That 'Ignore' Stress, Lead to Heart Failure.  // Ascribe Newswire: Medicine;4/6/2004, p28 

    Mayo Clinic researchers have discovered genetic mutations in heart patients that make them vulnerable to heart failure because they produce an abnormal protein that can't decode stress messages from the body. Research team leader Andre Terzic, a specialist in cardiac biology, describes the work...

  • Randomised trial of telephone intervention in chronic heart failure: DIAL trial. Grancelli, H. // BMJ: British Medical Journal (International Edition);8/20/2005, Vol. 331 Issue 7514, p425 

    Objective: To determine whether a centralised telephone intervention reduces the incidence of death or admission for worsening heart failure in outpatients with chronic heart failure. Design: Multicentre randomised controlled trial. Setting: 51 centres in Argentina (public and private hospitals...

  • Anaemia and heart failure. Coats, A. J. S. // Heart;Sep2004, Vol. 90 Issue 9, p977 

    Chronic heart failure is frequently associated with poor exercise tolerance and debilitating symptoms despite optimal modern treatment. In the past we expected that this was due to the direct consequences of poor output and congested lungs. The severity of symptomatic exercise limitation varies...

  • Ethnic differences in patient perceptions of heart failure and treatment: the West Birmingham heart failure project. Lip, G. Y. H.; Khan, H.; Bhatnagar, A.; Brahmabhatt, N.; Crook, P.; Davies, M. K. // Heart;Sep2004, Vol. 90 Issue 9, p1016 

    Objective: To investigate further the hypothesis that ethnic groups would have different levels of knowledge and perceptions of congestive heart failure (CHF) and treatments for this condition, a cross sectional survey was conducted of patients who were attending the heart failure clinics in two...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics