Effect of Lidoflazine on Systemic Arteries and Veins

Vanhoutte, Paul M.; Verbeuren, Tony J.; Van Neuten, Jan M.
September 1980
Angiology;Sep1980, Vol. 31 Issue 9, p581
Academic Journal
Studies the direct effects of lidoflazine on arterial and venous smooth muscle. Materials and methods; Concentration-dependent depression of the amplitude of the spontaneous contractions; Effect of increasing concentrations of lidoflazine; Influence of the increasing concentrations of lidoflazine on the response to electrical stimulation.


Related Articles

  • REACTIONS OF VENOUS SMOOTH MUSCLE IN NORMAL MEN AND PATIENTS WITH VARICOSE VEINS. Thulesius, Olav; Gj�res, J. E. // Angiology;Feb1974, Vol. 25 Issue 2, p145 

    The present investigation reports about isometric contraction of isolated vein preparations obtained from normal subjects and patients with varicose veins. The spirally cut vein preparations represented various stages of wall changes due to increasing varicosity. The degree of local vascular...

  • Vascular Remodeling in Varicose Veins. Kockx, Mark M.; Knaapen, Michiel W. M.; Bortier, Hilde E.; Cromheeke, Kristel M.; Boutherin-Falson, Odile; Finet, Michel // Angiology;Nov1998, Vol. 49 Issue 11, p871 

    The present study describes the histopathologic aspects of varicose (n=29; mean age, 52 ±12 years) and normal saphenous veins (n=17; mean age, 51 ±12 years) of patients from a similar age group. We focused on the changes that occur in the circular layer of the venous wall. We examined the...

  • The Histopathology of Varicose Vein Disease. Somers, Pamela; Knaapen, Michiel // Angiology;Oct/Nov2006, Vol. 57 Issue 5, p546 

    Varicosity is a complex venous pathology affecting the lower extremities. The exact etiology and physiopathology of varicose vein disease remain, however, unclear. Several theories exist from incompetence of the valves to a disturbance of the smooth muscle cells (SMC) and extra-cellular matrix...

  • Vascular leiomyosarcoma of thigh - A rare tumour at an unusual site. Roy, Asitava Deb; Deka, Muktanjalee; Dutta, Umesh Chandra // Australasian Medical Journal;Oct2013, Vol. 6 Issue 10, p520 

    Leiomyosarcomas of vascular origin are rare. They originate from the smooth muscles of tunica media of major blood vessels. The majority of such tumours arising in the extremities affect the femoral vascular bundle. There is limited knowledge and experience of the clinical presentation,...

  • N-Acetylcysteine Does Not Improve the Endothelial and Smooth Muscle Function in the Human Saphenous Vein. Sharif, Muhammad Anees; Bayraktutan, Ulvi; Young, Ian Stuart; Chee Voon Soong // Vascular & Endovascular Surgery;Jun/Jul2007, Vol. 41 Issue 3, p239 

    Oxidative stress can lead to vein graft dysfunction in the saphenous vein. This ex vivo study is aimed to compare the effects of increasing concentrations of the antioxidant N-acetylcysteine (NAC) with heparinized saline (HS) on endothelial and smooth muscle function in the human saphenous vein....

  • Chronic ethanol consumption induces hypomotility in the portal vein of Sardinian alcohol-preferring rats. LICHERI, D.; VARGIU, R.; DEL MONACO, S.; FADDA, F.; MANCINELLI, R. // Alcohol & Alcoholism;Mar1999, Vol. 34 Issue 2, p169 

    In order to study the physiopathological effects of chronic ethanol intake on the smooth muscle of the vascular system, we have assessed the length-tension relationship in isolated portal veins of Sardinian alcohol-preferring (sP) rats. Significant differences in motor performance were found...

  • Preventing intimal thickening of vein grafts in vein artery bypass using STAT-3 siRNA.  // Journal of Translational Medicine;2012, Vol. 10 Issue 1, p2 

    The article offers information on the study conducted by the authors related to prevention of intimal thickening of vein grafts in vein artery bypass using STAT-3 siRNA. It states that proliferation and migration of vascular smooth muscle cells (VSMCs) play a key role in neointimal formation...

  • Caveolins in vascular smooth muscle: Form organizing function. Hardin, Christopher D.; Vallejo, Johana // Cardiovascular Research;Mar2006, Vol. 69 Issue 4, p808 

    Abstract: Caveolae are becoming increasingly recognized as an important organizational structure for a variety of signal and energy-transducing systems in vascular smooth muscle (VSM). In this review, we discuss the emerging role of the caveolins in organizing and modulating the basic functions...

  • Endothelial Injury Induces Vascular Smooth Muscle Cell Proliferation in Highly Localized Regions of a Direct Contact Co-culture System. Joyce Wong // Cell Biochemistry & Biophysics;Sep2008, Vol. 52 Issue 1, p37 

    Abstract  Though previous studies have indicated a relationship between the proliferation of endothelial cells and vascular smooth muscle cells (VSMCs) in co-culture, the results have been contradictory and the signaling mechanism poorly understood. In this transmembrane co-culture study,...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics