Groover Jr., M. E.; Seljeskog, E. L.; Haglin, J. J.; Hitchcock, C. R.
August 1963
Angiology;Aug1963, Vol. 14 Issue 8, p409
Academic Journal
Electrocardiograms were done on wild African baboons soon after their capture in the bush country of Kenya. Forty-nine satisfactory tracings were obtained. Seven of these were considered abnormal. The coronary system of these hearts was studied by means of vinyl plastic casts of the vascular tree. Healed myocardial scars were noted in five. In one other, a fibrin-covered fresh infarct was found. Another was found to have, in addition to widening of the QRS complex in the electrocardiogram, a rupture of the coronar>' artery supplying the upper part of the septum. This may have occurred previously or during the perfusion of the coronary vessels. Some of the literatur concerning subendocardial arterioles of the coronary system has been considered. The emotional storm induced by trapping and caging wild baboons is suggested as an important factor in the etiology of lesions described here. The report of rapid lowering of venous blood lipids by Werthessen and associates and the recent work of Gunn and co-workers produced subendocardial hemorrhage with electrical stimulation of the vagus nerve, may prove to open new avenues of approach to the study of the problem of myocardial infarction. The baboon promises to be an excellent animal for the study of both the metabolic disorders incident to atherosclerosis and the neurovascular changes which may be the triggering mechanism for myocardial infarction. A working hypothesis for the future study of myocardial infarction could be outlined as follows 1. Nerve impulses to coronary vessels produce vasospasm. 2. Repeated vasospastic episodes produce mild injury to intima resulting in intimal thickening. 3. If there is an overabundance of calories in the diet, lipid material is accumulated in the intima and subintima. 4. Neurogenic factors cause mobilization of lipids from portal storage area, which increases the clotting tendency of the blood and makes this animal more susceptible to thromboembolic phenomena.


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